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JNJ-26990990

Name: JNJ-26990990
Brand: TargetMol
SKU: T27673
Price: 780 CNY
Availability: InStock
Rating: 5 (10 reviews)

货号 T27673Cas号 877316-38-6 一键复制产品信息纯度: 97.37%

很棒

JNJ-26990990 是一种广谱抗惊厥药，是上市药物托吡酯的第二代后续药物。它被设计成具有与托吡酯相同的抗惊厥作用，但没有与托吡酯的碳酸酐酶抑制相关的副作用。它还具有治疗炎症性疼痛、神经性疼痛和抑郁症的潜在用途。

JNJ-26990990

一键复制产品信息

很棒

纯度: 97.37%

货号 T27673Cas号 877316-38-6

规格	价格	库存
1 mg	¥ 780	现货
5 mg	¥ 1,750	现货
10 mg	¥ 2,590	现货
25 mg	¥ 4,120	现货
50 mg	¥ 5,590	现货
100 mg	¥ 7,500	现货
1 mL x 10 mM (in DMSO)	¥ 1,490	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 97.37%

颜色: 白色

性状: Solid

资源下载: COA LCMS HNMR产品操作手册

产品介绍

JNJ-26990990 AI Summary

JNJ-26990990 is a bioactive agent with diverse pharmacological properties. It demonstrates inhibition of human carbonic anhydrase 2 with IC50 values of 110,000.0 nM and 66,000.0 nM in different assay methods. It also exhibits anticonvulsant activity in various seizure models in mice and rats, with effective doses (ED50) ranging from 21.0 mg/kg to 161.0 mg/kg, and exhibits neurotoxicity in mice and rats, with a TD50 of 182.0 mg/kg in mice and >500.0 mg/kg in rats. Additionally, JNJ-26990990 inhibits rat sodium and calcium channels and shows moderate inhibitory effects on NMDA and kainate receptors in mouse cortical neurons, as well as low-potency activation of GABA receptors in these neurons. The compound reveals antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 μM concentration after 48 hours (inhibition of 30.92%), though its inhibition of SARS-CoV-2 3CL-Pro protease is modest at 15.85% at 20 μM concentration. It demonstrates minimal inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at similar concentrations, with an IC50 value greater than 20,000.0 nM. JNJ-26990990 exhibits a 4.78% inhibition on human HDAC6 with a commercial peptide substrate, but a -5.64% inhibition with a custom peptide substrate, indicating possible selectivity towards different substrates. It displays metabolic stability in liver microsomes and plasma across species, with good bioavailability in mice and rats (F values ranging from 59.0% to 96.0%) and favorable pharmacokinetic properties in terms of clearance, half-life, volume of distribution, and plasma concentrations in these animals..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述

JNJ-26990990 is a broad-spectrum anticonvulsant drug as a second-generation followup to the marketed drug topiramate. It was designed to have the same anticonvulsant effects as topiramate, but without the side effects associated with topiramate's carbonic anhydrase inhibition. It also has potential use in the treatment of inflammatory pain, neuropathic pain, and depression. JNJ-26990990 entered phase II clinical trials in October 2007.

化学信息

分子量	242.32
分子式	C₉H₁₀N₂O₂S₂
CAS No.	877316-38-6
Smiles	C(NS(N)(=O)=O)C=1C=2C(SC1)=CC=CC2
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 65 mg/mL (268.24 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1268 mL	20.6339 mL	41.2677 mL	206.3387 mL
5 mM	0.8254 mL	4.1268 mL	8.2535 mL	41.2677 mL
10 mM	0.4127 mL	2.0634 mL	4.1268 mL	20.6339 mL
20 mM	0.2063 mL	1.0317 mL	2.0634 mL	10.3169 mL
50 mM	0.0825 mL	0.4127 mL	0.8254 mL	4.1268 mL
100 mM	0.0413 mL	0.2063 mL	0.4127 mL	2.0634 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。