Idebenone-SS-20 (Idebenone-2S-FrFK-NH2) is a derivative of Idebenone conjugated with the mitochondrial-targeting peptide SS-20. It exhibits neuroprotective and anti-inflammatory properties. This compound maintains mitochondrial membrane potential, enhances ATP production, reduces reactive oxygen species (ROS) accumulation, preserves mitochondrial morphology, and increases the NAD+/NADH ratio. In a transient middle cerebral artery occlusion mouse model, Idebenone-SS-20 demonstrates potent neuroprotective effects and can be utilized in studies related to cerebral ischemia-reperfusion injury.

Idebenone-2S-FrFK-NH2