Etoxadrol (CL-1848C) (100.0 mg/kg; i.h.; once) produces significant stimulation and ataxia in mice [2]. Etoxadrol (0-20 mg/kg; i.v.; once) reduces brain monoamine concentrations after 4 h injection [3]. Animal Model: Carworth-Farm (Upjohn) male mice weighing 18 to 20 gm [2] Dosage: 100.0 mg/kg Administration: Subcutaneous injection, 30 min Result: Produced significant stimulation and ataxia. Animal Model: Male CFE rats weighing 110-175 g (average 130 g) [3] Dosage: 5, 10, and 20 mg/kg Administration: Intravenous injection, once Result: Significantly reduce brain serotonin, DA (dopamine), and NE (norepinephrine) concentrations at 4 h.