DDD01035881 is a novel and highly potent anti-malarial drug that blocks parasite-to-mosquito transmission with nanomolar activity by targeting the Plasmodium vesicle membrane protein Pfs16 and blocking the formation of male gametes in the life cycle of the malaria parasite.

DDD01035881（5 μM）选择性阻断恶性疟原虫雄配子体形成，作用具有时间依赖性。激活后5分钟内用药会抑制外翻和细胞骨架形成，虽有DNA复制，但结构异常[1]。DDD01035881干扰Pfs16在疟原虫雄配子形成过程中的定位与功能，阻断PVM（寄生泡膜）的囊泡化和释放，导致配子体无法正常或完全脱离红细胞[1]。