Name: Cyclo(RGDfC) TFA
Brand: TargetMol
SKU: T76068
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

1 mg

¥ 218

待询

5 mg

¥ 899

现货

生物活性

产品描述	Cyclo(RGDfC) TFA (Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA) is a cyclic pentapeptide, a cyclic RGD polypeptide with high affinity for αvβ3, which is capable of disrupting cellular integrin interactions. Cyclo(RGDfC) TFA inhibits pluripotent gene expression in embryonic stem cells (ESCs) and inhibits tumorigenic potential of mESCs in vivo. Cyclo(RGDfC) TFA inhibits the tumorigenic potential of mESC. Cyclo(RGDfC) TFA can be used for tumor-related studies.
体外活性	0.5 mM Cyclo(RGDfC) TFA，处理24小时能够下调mESC中的转录因子Oct 4、Sox 2和Nanog的表达，并抑制mESC-col I（I型胶原蛋白）构建中的整合素基因表达。此外，处理后的mESC细胞会形成团聚体并从表面脱离。[1]
体内活性	0.5 mM Cyclo(RGDfC) TFA，处理24小时，处理的mESC在有或没有白血病抑制因子（LIF）的条件下（通过双腿注射），抑制了严重联合免疫缺陷（SCID）小鼠的畸胎瘤形成。[1]
别名	Cyclo(RGDfC) 三氟乙酸盐, Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA

化学信息

分子量	692.67
分子式	C₂₆H₃₅F₃N₈O₉S
Smiles	O=C([C@@H](NC(CNC([C@@H](NC([C@@H](NC1=O)CS)=O)CCCNC(N)=N)=O)=O)CC(O)=O)N[C@@H]1CC2=CC=CC=C2.OC(C(F)(F)F)=O
Sequence	cyclo[DL-Arg-Gly-DL-Asp-DL-Phe-DL-Cys]
Sequence Short	(cyclo)-RGDFC-(cyclo)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

H2O: 10 mg/mL (14.44 mM), Sonication is recommended.

溶液配制表

H2O

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

Cyclo(RGDfC) TFA