PROTAC CARM1 degrader-2 (compound 3e), with a DC50 value of 8.8 nM, is a VHL- and proteasome-dependent degrader of co-activator associated argininemethyltransferase (CARM1). It not only promotes the degradation of CARM1 but also prevents the methylation of its substrates, including poly(A)-binding protein PABP1 and BGR1-associated factor BAF155, which consequently inhibits breast cancer cell migration [1].