pgi2 receptor

Carbacyclin, a PGI2 analog, is a prostacyclin (PGI2) receptor agonist and vasodilator with potent inhibitory platelet aggregation.

Carbaprostacyclin-biotin (cPGI-biotin;Carbacyclin-biotin) 是Carbacyclin (Carbaprostacyclin) 与生物素结合的化合物。Carbacyclin 是 PGI2 的类似物，作为前列环素 (PGI2) 受体激动剂和血管扩张剂，能够有效抑制血小板聚集。

ONO 1301 是一种前列环素（PGI2）拟似物，并具有抑制血栓烷 A2 合成酶的活性。在 DBTC 诱导的慢性胰腺炎模型中，ONO 1301 通过其直接作用及诱导肝细胞生长因子（HGF）产生、抑制单核细胞活性，从而抑制胰腺纤维化。ONO 1301 还可通过 IP 受体信号促进 HGF 合成并升高细胞内 cAMP 水平，凸显ONO 1301 在纤维化疾病和炎症研究中的治疗潜力。

6β-PGI1 is a stable PGI2 analog resistant to hydrolysis in aqueous solutions. 6β-PGI1 has a much longer half-life than PGI2, but a greatly reduced molar potency for receptor mediated function. 6β-PGI1 has a Kact for adenylate cyclase in NCB-20 cells of 4.2 μM compared with 18 nM for PGI2. The potency for vasodilation and inhibition of platelet aggregation is about 1% of PGI2.