Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Brompheniramine ((±)-Brompheniramine) 是具有口服活性的烷基胺类抗组胺药。Brompheniramine 是组胺 H1 受体的选择性拮抗剂 (Kd = 6.06 nM)。Brompheniramine 可用于过敏性鼻炎,它具有抗胆碱能、抗抑郁和麻醉作用。Brompheniramine 可阻断钙离子通道、钠离子通道和 hERG 通道,IC50分别为 16.12 μM, 21.26 μM 和 0.90 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 6-8周 | ||
50 mg | ¥ 13,800 | 6-8周 | ||
100 mg | ¥ 17,500 | 6-8周 |
Brompheniramine 的其他形式现货产品:
产品描述 | Brompheniramine ((±)-Brompheniramine) is a potent and orally active alkylamine class antihistamine. Brompheniramine is a selective antagonist of histamine H1 receptor (Kd = 6.06 nM). Brompheniramine can be used in the research of allergic rhinitis that has anticholinergic, antidepressant and anesthetic properties. Brompheniramine can block the calcium channels, sodium channels, and hERG channels with IC 50 s of 16.12 μM, 21.26 μM, and 0.90 μM, respectively [1] [2] [3] [4]. |
体外活性 | Brompheniramine (0.1-100 μM) blocks hERG K + channels expressed in CHO cells in a concentration-dependent manner with an IC 50 of 0.90±0.14 μM, and reduced peak tail current amplitude measured at -60 mV (cells are depolarized for 2 s to +20 mV from a holding potential of -80 mV followed by a 3s repolarization back to -60 mV) [3]. Brompheniramine (1, 10 and 100 μM) significantly shortens the APD 50 and depresses the plateau phase on the action potential in guinea pig papillary muscle, as well as slightly prolongs the APD 90 in guinea pig papillary muscle at 10 and 100 μM [3]. Brompheniramine (0.1-100 μM) inhibit the amplitude of the Ca 2+ channel currents in rat ventricular myocytes by 14.1±1.1, 31.1±5.8, 38.0±3.8 and 90.2±3.7% at 0.1, 1, 10 and 100 μM, respectively [3]. Brompheniramine blocks muscarinic cholinergic receptors in human chinese hamster ovary (CHO) cells [4]. |
体内活性 | Brompheniramine (0.3-3 μM; SC, single dosage) induces cutaneous analgesia in rats [1]. Animal Model: Male Sprague-Dawley rats [1] Dosage: 0.3, 0.6, 1.1, 1.5 and 3.0 μM Administration: SC, single dosage Result: Provoked cutaneous analgesia in a dose-dependent manner, with an EC 50 value of 0.66 μM, and induced prolonged analgesic duration. |
分子量 | 319.24 |
分子式 | C16H19BrN2 |
CAS No. | 86-22-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Brompheniramine 86-22-6 Inhibitor inhibitor inhibit