Name: Anti-IL-5 Antibody
Brand: TargetMol
SKU: T9901A-1408
Rating: 4.5 (1 reviews)

生物活性

产品描述	Anti-IL-5 Antibody (e.g., Mepolizumab) is a humanized monoclonal antibody that specifically neutralizes interleukin-5 (IL-5), effectively disrupting the signaling for eosinophil activation and survival by blocking the ligand-receptor interaction. In allergic inflammation models, this antibody significantly diminishes tissue eosinophil infiltration and alleviates airway hyperresponsiveness.
体内活性	在嗜酸性哮喘模型中，Anti-IL-5 Antibody能显著减少痰液和血液中的嗜酸性粒细胞。然而在存在抗 IL-5 IgG 自身抗体的重症哮喘研究中，该药物可能在气道内被整合隔离，导致无法有效中和局部 IL-5，从而引起持续的嗜酸性粒细胞增多 [2]。
别名	抗IL-5抗体
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型	IgG4 (S228P)
推荐同型对照	Human IgG4 (S228P) kappa, Isotype Control

偶联与修饰

偶联	Unconjugated

抗原信息

Uniprot ID	P05113
靶点	IL-5

储存&溶解度

存储

Anti-IL-5 Antibody