规格

价格

库存

数量

25 mg

待询

生物活性

产品描述

Aeruginosin 865, a compound extracted from the terrestrial cyanobacterium Nostoc sp. Luke ová 30/93, represents the inaugural aeruginosin-type peptide to incorporate a fatty acid and a carbohydrate moiety. It functions by inhibiting the translocation of NF-kB to the nucleus, thereby exerting an anti-inflammatory effect.

体外活性

Aeruginosin 865 (pretreatment with 0.1-100 μg/mL) shows significant inhibition of IL-8 (EC 50 =3.5 μg/mL) and ICAM-1 (EC 50 =50.0 μg/mL) in hTNF-α-stimulated HLMVECs in a concentration-dependent manner. Aeruginosin 865 does not affect cell viability, even at much higher concentration in HeLa, HepG2 cells[1]. Aeruginosin 865 (100-200 μM) shows high-dose cytotoxicity in Mouse fibrosarcoma cells and with no cytotoxic effect in NIH/3T3 cells[2]. .

化学信息

分子量	864.991
分子式	C₄₁H₆₄N₆O₁₄
CAS No.	1611990-01-2
Smiles	[H][C@]12C[C@@H](N(C(=O)[C@@H](CC(C)C)NC(=O)[C@H](O)Cc3ccc(O)cc3)[C@@]1([H])C[C@H](O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@@H]1O)C(O)=O)[C@H](C2)OC(=O)CCCCC)C(=O)NCCCCNC(N)=N
密度	no data available