Venlafaxine

Name: Venlafaxine
Brand: TargetMol
SKU: T22453
Price: 109 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.2%

货号 T22453Cas号 93413-69-5

别名 文拉法辛, Wy 45030

Venlafaxine (Wy 45030) 是一种口服有效的 5-羟色胺 (5-HT)/去甲肾上腺素 (NE) 重摄取的双重抑制剂，具有抗抑郁活性。

Venlafaxine

一键复制产品信息

很棒

纯度: 99.2%

货号 T22453 别名 文拉法辛, Wy 45030Cas号 93413-69-5

Venlafaxine (Wy 45030) 是一种口服有效的 5-羟色胺 (5-HT)/去甲肾上腺素 (NE) 重摄取的双重抑制剂，具有抗抑郁活性。

规格	价格	库存
1 mg	¥ 109	现货
5 mg	¥ 213	现货
10 mg	¥ 345	现货
25 mg	¥ 638	现货
50 mg	¥ 828	现货
100 mg	¥ 938	现货
500 mg	¥ 2,330	现货
1 mL x 10 mM (in DMSO)	¥ 243	现货

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纯度: 99.2%

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资源下载:

COA HNMR LCMS HPLC 产品操作手册

产品介绍

Venlafaxine AI Summary

Venlafaxine exhibits high affinity for the serotonin transporter (SERT) with a Ki value ranging from 8.9 nM to 52 nM, and moderate affinity for the norepinephrine transporter (NET) with Ki values spanning from 210 nM to 1623 nM. It shows weak binding to the dopamine transporter (DAT) with Ki values as high as 9300 nM. The compound functions as a potent inhibitor of both serotonin reuptake (IC50 = 20 nM to 323.59 nM) and norepinephrine reuptake (IC50 = 140 nM to 149.0 nM), with a significantly lesser effect on dopamine reuptake (IC50 > 1000 µM). Pharmacokinetically, it has moderate volume distribution (Vdss = 4.4 L.kg^-1) and exhibits high unbound fraction in plasma (Fu = 0.73). It is metabolically stable in human liver microsomes with intrinsic clearance (CL) of 59.0 mL.min^-1.g^-1. Venlafaxine has demonstrated antidepressant and anxiolytic activities in animal models, as well as an antiallodynic effect in nerve injury rats. Additionally, it shows good oral bioavailability in humans (Fa = 97%) and has moderate liver toxicity indicators. Venlafaxine does not cause severe drug-induced liver injury (DILI) and has displayed antiviral activity against SARS-CoV-2 in specific cellular assays..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Venlafaxine (Wy 45030), an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), is used to treat major generalised anxiety disorder (GAD), depressive disorder (MDD), panic disorder and social phobia.
别名	文拉法辛, Wy 45030

化学信息

分子量	277.4
分子式	C₁₇H₂₇NO₂
CAS No.	93413-69-5
Smiles	COc1ccc(cc1)C(CN(C)C)C1(O)CCCCC1
密度	1.060 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 245 mg/mL (883.2 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6049 mL	18.0245 mL	36.0490 mL	180.2451 mL
5 mM	0.7210 mL	3.6049 mL	7.2098 mL	36.0490 mL
10 mM	0.3605 mL	1.8025 mL	3.6049 mL	18.0245 mL
20 mM	0.1802 mL	0.9012 mL	1.8025 mL	9.0123 mL
50 mM	0.0721 mL	0.3605 mL	0.7210 mL	3.6049 mL
100 mM	0.0360 mL	0.1802 mL	0.3605 mL	1.8025 mL