Powder: -20°C for 3 years | In solvent: -80°C for 1 year
KYP-2047 是一种非常有效的选择性脯氨酰寡肽酶 (POP) 抑制剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 445 | 现货 | ||
2 mg | ¥ 648 | 现货 | ||
5 mg | ¥ 1,080 | 现货 | ||
10 mg | ¥ 1,580 | 现货 | ||
25 mg | ¥ 2,890 | 现货 | ||
50 mg | ¥ 4,320 | 现货 | ||
100 mg | ¥ 6,490 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,190 | 现货 |
产品描述 | KYP-2047 is a very potent, selective Prolyl oligopeptidase (POP) inhibitor. |
体外活性 | In cell lines, oxidative stress induced a robust aggregation of α-synuclein,and low concentrations of KYP-2047 significantly reduced the number of cells with α-synuclein inclusions while abolishing the colocalization of α-synuclein and PREP. KYP-2047 significantly reduced the amount of aggregated α-synuclein,and it had beneficial effects on cell viability.?In the transgenic mice, a 5-day treatment with the PREP inhibitor reduced the amount of α-synuclein immunoreactivity and soluble α-synuclein protein in the brain[1]. |
分子量 | 339.43 |
分子式 | C20H25N3O2 |
CAS No. | 796874-99-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (73.65 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.9461 mL | 14.7306 mL | 29.4612 mL | 73.6529 mL |
5 mM | 0.5892 mL | 2.9461 mL | 5.8922 mL | 14.7306 mL | |
10 mM | 0.2946 mL | 1.4731 mL | 2.9461 mL | 7.3653 mL | |
20 mM | 0.1473 mL | 0.7365 mL | 1.4731 mL | 3.6826 mL | |
50 mM | 0.0589 mL | 0.2946 mL | 0.5892 mL | 1.4731 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
KYP-2047 796874-99-2 Others eNOS inhibit POP Neurotensin Angiopoietins MDM-2/p53 KYP 2047 prolyl oligopeptidase Glioblastoma VEGF KYP2047 Prolyl Endopeptidase (PREP) Inhibitor U-87 cell Apoptosis inhibitor