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Ergosterol

Name: Ergosterol
Brand: TargetMol
SKU: T2912
Price: 187 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.1%

货号 T2912Cas号 57-87-4

别名 麦角固醇, Provitamin D2, Provitamin D, Ergosterin

Ergosterol 是真菌中的主要固醇类，具有抗炎，抗氧化和抗增殖的作用。

Ergosterol

一键复制产品信息

很棒

纯度: 98.1%

货号 T2912 别名 麦角固醇, Provitamin D2, Provitamin D, ErgosterinCas号 57-87-4

Ergosterol 是真菌中的主要固醇类，具有抗炎，抗氧化和抗增殖的作用。

规格	价格	库存
25 mg	¥ 187	现货
50 mg	¥ 257	现货
100 mg	¥ 356	现货
500 mg	¥ 745	现货
1 g	¥ 1,090	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 98.1%

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Ergosterol AI Summary

Ergosterol exhibits multifaceted bioactivities, including anti-inflammatory, antibacterial, antiviral, and anticancer properties. It inhibits NO production with IC50 values of 27,900 nM in NOX inhibition in fMLP-induced PMN cells and 30,600 nM in iNOS inhibition in mouse BV2 microglial cells, suggesting potential modulation of inflammatory pathways. It demonstrates antibacterial activity against Legionella pneumophila Corby with an MIC of 250.0 µg/mL, and also inhibits the growth of Pseudomonas aeruginosa and Staphylococcus aureus with inhibition zones of 8.7 mm and 11.2 mm respectively at a concentration of 2 mg/mL. Antiviral activities include inhibiting SARS-CoV-2-induced cytotoxicity in Caco-2 and VERO-6 cells at 10 µM concentration, with respective inhibition rates of 11.1% and 0.04%. The compound also shows 2.051% inhibition of SARS-CoV-2 3CL-Pro protease at 20 µM concentration. In addition, it inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells by 31.68% and 52.34% at 10 µM, respectively. In cancer research, Ergosterol demonstrates cytotoxicity against various cell lines, including mouse L5178Y (EC50: 12,600 nM), human COLO 205 (IC50: 4,900 nM), COLO 320 (IC50: 6,500 nM), and MRC5 (IC50: 500 nM). It shows antiproliferative activity against human NCI-H157 and A549 cells, with IC50 values of 23,300 nM and 19,200 nM, respectively. Significant antitumor activity is observed in xenografted mouse models with Lewis lung cancer cells, with 100% growth inhibition at 12.5 µg/mL after 48 hours and evidence of metastasis inhibition or tumor regression. Despite some toxicity-related net weight reduction, the compound maintains 100% survival rates in treated mouse models. Additionally, Ergosterol exhibits specific bioactivities such as inhibiting TNFalpha-induced NF-kappaB activity in HeLa cells with an IC50 of 0.91 µg/mL and inhibiting human HDAC6 with 26.56% inhibition in an enzymatic assay. However, it shows no activity against UGT1A1 and slight negative inhibition in a custom peptide substrate HDAC6 assay. The compound also potentiates doxorubicin-induced cytotoxicity by inhibiting P-glycoprotein activity in COLO 320 cells..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Ergosterol is the major sterol in fungi and has anti-inflammatory, antioxidant and antiproliferative properties.
别名	麦角固醇, Provitamin D2, Provitamin D, Ergosterin

化学信息

分子量	396.65
分子式	C₂₈H₄₄O
CAS No.	57-87-4
Smiles	C[C@@]12[C@](C=3[C@@]([C@]4(C)C(=CC3)C[C@@H](O)CC4)(CC1)[H])(CC[C@@]2([C@@H](/C=C/[C@@H](C(C)C)C)C)[H])[H]
密度	1.04 g/cm3. Temperature:20 °C.

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

Tert-butanol: 18 mg/mL (45.38 mM)

DMSO: < 1 mg/mL (insoluble)

Ethanol: 2 mg/mL (5.04 mM)

H2O: Insoluble

溶液配制表

Ethanol/Tert-butanol

	1mg	5mg	10mg	50mg
1 mM	2.5211 mL	12.6056 mL	25.2111 mL	126.0557 mL
5 mM	0.5042 mL	2.5211 mL	5.0422 mL	25.2111 mL

Tert-butanol

	1mg	5mg	10mg	50mg
10 mM	0.2521 mL	1.2606 mL	2.5211 mL	12.6056 mL
20 mM	0.1261 mL	0.6303 mL	1.2606 mL	6.3028 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Provitamin D-2 Provitamin D 2 Ergosterol EndogenousMetabolite Endogenous Metabolite antioxidant

Ergosterol

Ergosterol

Ergosterol 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

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