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4-Methylhistamine hydrochloride

Name: 4-Methylhistamine hydrochloride
Brand: TargetMol
SKU: T50049
Price: 593 CNY
Availability: InStock
Rating: 5 (10 reviews)

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纯度: 95%

货号 T50049Cas号 84103-51-5

4-Methylhistamine hydrochloride 已被证明能抑制铜依赖性酶如酪氨酸酶和多巴胺β-羟化酶的活性，还被证明可以调节参与细胞周期调节和凋亡的基因的表达。

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4-Methylhistamine hydrochloride

一键复制产品信息

很棒

纯度: 95%

货号 T50049Cas号 84103-51-5

4-Methylhistamine hydrochloride 已被证明能抑制铜依赖性酶如酪氨酸酶和多巴胺β-羟化酶的活性，还被证明可以调节参与细胞周期调节和凋亡的基因的表达。

规格	价格	库存
1 mg	¥ 593	现货
2 mg	¥ 887	现货
5 mg	¥ 1,370	现货
10 mg	¥ 1,990	现货
25 mg	¥ 3,510	现货
50 mg	¥ 4,970	现货
100 mg	¥ 7,220	现货
500 mg	¥ 14,300	待询
1 mL x 10 mM (in DMSO)	¥ 966	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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产品介绍

4-Methylhistamine hydrochloride AI Summary

4-Methylhistamine hydrochloride exhibits a multifaceted bioactivity profile. It demonstrates in vivo agonist activity at the histamine H2 receptor in rats, effectively stimulating gastric acid secretion. In vitro, it acts as an agonist at the histamine H1 receptor in guinea pig ileum, albeit to a much lower extent. Cell viability assays indicate that 4-Methylhistamine hydrochloride promotes positive growth rates in HEK293T cells, human fibroblasts, and some U2OS cells, but negatively affects growth rates in other U2OS cell assays, suggesting cell type-dependent bioactivity. Thermal stability assays reveal that the compound has varying effects on the melting temperatures of different protein domains, decreasing TM in some by up to -2.22 degrees Celsius and increasing it by up to 1.12 degrees Celsius in others. Additionally, GPCR beta-arrestin recruitment assays show that 4-Methylhistamine hydrochloride exerts inhibitory effects on several targets including ADGRF1, FFAR4, and ADRB2, with inhibition ranging from -36.82% to -0.04%, while also stimulating targets such as CX3CR1 and GPR119, with maximum stimulation reaching up to 27.94%. Furthermore, the compound has been characterized using thin layer chromatography, demonstrating specific retardation factors using different solvent systems. This diverse bioactivity suggests that 4-Methylhistamine hydrochloride has complex pharmacological properties and interacts differentially across various biological targets and conditions..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	4-Methylhistamine hydrochloride has been shown to inhibit the activity of copper-dependent enzymes such as tyrosinase and dopamine beta-hydroxylase and has also been shown to modulate the expression of genes involved in cell cycle regulation and apoptosis.

化学信息

分子量	161.633
分子式	C₆H₁₂ClN₃
CAS No.	84103-51-5
Smiles	Cl.CC1=C(CCN)NC=N1
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (340.28 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.1869 mL	30.9343 mL	61.8686 mL	309.3428 mL
5 mM	1.2374 mL	6.1869 mL	12.3737 mL	61.8686 mL
10 mM	0.6187 mL	3.0934 mL	6.1869 mL	30.9343 mL
20 mM	0.3093 mL	1.5467 mL	3.0934 mL	15.4671 mL
50 mM	0.1237 mL	0.6187 mL	1.2374 mL	6.1869 mL
100 mM	0.0619 mL	0.3093 mL	0.6187 mL	3.0934 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

4-Methylhistamine Hydrochloride 2(5methyl1Himidazol4yl)ethan1amine hydrochloride 2 (5 methyl 1H imidazol 4 yl)ethan 1 amine hydrochloride

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4-Methylhistamine hydrochloride

4-Methylhistamine hydrochloride