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顶部相关产品产品介绍化学信息储存和溶解信息计算器

15(R)-Lipoxin A4

Synonyms: AT-Lipoxin A4, 15(R)-Lipoxin A4
货号 T37265Cas号 171030-11-8 一键复制产品信息
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Lipid-derived lipoxins are produced at the site of vascular and mucosal inflammation where they down-regulate polymorphonuclear leukocyte recruitment and function. 15(R)-Lipoxin A4 (15(R)-LXA4) is derived from the aspirin-triggered formation of 15(R)-HETE from arachidonic acid. [1] [2] 15(R)-LXA4 inhibits LTB4-induced chemotaxis, adherence, and transmigration of neutrophils with twice the potency of LXA4 demonstrating activity in the nM range.[2] [3] The anti-inflammatory effects of aspirin may be ascribed in part to the ability of 15(R)-LXA4 to regulate leukocyte function.[4] 15(R)-LXA4 is reported to promote resolution of inflammation in LPS-treated stromal cells derived from intermediate-stage diseased supraspinatus tendons as evidenced by increased expression of the STAT-6 pathway target genes, ALOX15 and CD206.[5]

15(R)-Lipoxin A4

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货号 T37265Cas号 171030-11-8

别名 AT-Lipoxin A4, 15(R)-Lipoxin A4

Lipid-derived lipoxins are produced at the site of vascular and mucosal inflammation where they down-regulate polymorphonuclear leukocyte recruitment and function. 15(R)-Lipoxin A4 (15(R)-LXA4) is derived from the aspirin-triggered formation of 15(R)-HETE from arachidonic acid. [1] [2] 15(R)-LXA4 inhibits LTB4-induced chemotaxis, adherence, and transmigration of neutrophils with twice the potency of LXA4 demonstrating activity in the nM range.[2] [3] The anti-inflammatory effects of aspirin may be ascribed in part to the ability of 15(R)-LXA4 to regulate leukocyte function.[4] 15(R)-LXA4 is reported to promote resolution of inflammation in LPS-treated stromal cells derived from intermediate-stage diseased supraspinatus tendons as evidenced by increased expression of the STAT-6 pathway target genes, ALOX15 and CD206.[5]

15(R)-Lipoxin A4
其他形式的 “15(R)-Lipoxin A4”:
6(S)-Lipoxin A4
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规格价格库存数量
25 μg
¥ 4,970
35日内发货
50 μg
¥ 9,680
35日内发货
100 μg
¥ 18,200
35日内发货
250 μg
¥ 39,700
35日内发货
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产品介绍

生物活性
产品描述
Lipid-derived lipoxins are produced at the site of vascular and mucosal inflammation where they down-regulate polymorphonuclear leukocyte recruitment and function. 15(R)-Lipoxin A4 (15(R)-LXA4) is derived from the aspirin-triggered formation of 15(R)-HETE from arachidonic acid. [1] [2] 15(R)-LXA4 inhibits LTB4-induced chemotaxis, adherence, and transmigration of neutrophils with twice the potency of LXA4 demonstrating activity in the nM range.[2] [3] The anti-inflammatory effects of aspirin may be ascribed in part to the ability of 15(R)-LXA4 to regulate leukocyte function.[4] 15(R)-LXA4 is reported to promote resolution of inflammation in LPS-treated stromal cells derived from intermediate-stage diseased supraspinatus tendons as evidenced by increased expression of the STAT-6 pathway target genes, ALOX15 and CD206.[5]
别名
AT-Lipoxin A4, 15(R)-Lipoxin A4
化学信息
分子量352.47
分子式C20H32O5
CAS No.171030-11-8
Smiles[C@H]([C@H](CCCC(O)=O)O)(/C=C/C=C/C=C\C=C\[C@@H](CCCCC)O)O
储存&溶解度
存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息
DMF: 50 mg/mL (141.86 mM), Sonication is recommended.
Ethanol: 50 mg/mL (141.86 mM), Sonication is recommended.
PBS (pH 7.2): 1 mg/mL (2.84 mM), Sonication is recommended.
溶液配制表
PBS (pH 7.2)/DMF/Ethanol
1mg5mg10mg50mg
1 mM2.8371 mL14.1856 mL28.3712 mL141.8560 mL
DMF/Ethanol
1mg5mg10mg50mg
5 mM0.5674 mL2.8371 mL5.6742 mL28.3712 mL
10 mM0.2837 mL1.4186 mL2.8371 mL14.1856 mL
20 mM0.1419 mL0.7093 mL1.4186 mL7.0928 mL
50 mM0.0567 mL0.2837 mL0.5674 mL2.8371 mL
100 mM0.0284 mL0.1419 mL0.2837 mL1.4186 mL
该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD， 玉米油等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

15Lipoxin A415(R)-Lipoxin A-415(R)Lipoxin A415(R) Lipoxin A4
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