wnk1

WNK-IN-11 (Allosteric WNK Kinase Inhibitor) 是(WNK)激酶的变构抑制剂，能够抑制 WNK1 (IC50:4 nM) 。

WNK1-IN-1 是 WNK1的选择性抑制剂，IC50值为 1.6 μM。WNK1-IN-1 抑制 OSR1 磷酸化，IC50值为 4.3 μM。WNK1-IN-1 可用于血压调节和癌症的研究。

WNK463 是口服有活性的 WNK 激酶抑制剂，能够抑制 WNK1 (IC50:5 nM)、WNK2 (IC50:1 nM)、WNK3 (IC50:6 nM)及 WNK4 (IC50:9 nM)。

WNK-IN-12 is an effective, selective, and orally active WNK1 kinase inhibitor.

WNK-IN-7 is a potent and selective WNK1 kinase inhibitor.

WNK-IN-B is an inhibitor of Wnk signalling. WNK-IN-B is a cell-permeable diaminoacridine derivative that targets the CCT domain of SPAK and OSR1 via reversible binding. WNK-IN-B selectively suppress hypotonic shock-induced WNK signaling pathway activation