th1 cytokine

Resiniferatoxin ((+)-Resiniferatoxin)是一种超强效合成的 TRPV1 激动剂, 抑制 Th1 细胞因子的产生，并具有抗炎活性，可降低血清IL-12、INF-γ、IL-1β、TNF-α、NO和PGE的水平。

TAK-603 is an anti-rheumatic drug and is also anti-inflammatory compound. It selectively suppresses Th1 cytokine production and inhibits the progression of adjuvant arthritis.

PBI-1393 can be used as an enhancer for Th1 type cytokine production and primary T cell activation.

Soquelitinib(CPI-818)是一种共价，不可逆，可口服和选择性的ITK抑制剂, 优先抑制Th2细胞因子的产生而非Th1，抑制小鼠肿瘤的体内生长，并且降低T细胞衰竭标志物，使正常CD8细胞的肿瘤浸润增加和CXCR3、IFNγ、TNFα和CD107a表达上调。

Physalin H is an Hh signaling inhibitor blocks GLI1-DNA-complex formation, it also strong quinone reductase induction activity with IR (Induction ratio, QR induction activity) value of 3.74±0.02. Physalin H shows immunosuppressive effects on T cells both

MOG (35-55) TFA 是中枢神经髓鞘的一个次要成分，具有致脑炎活性，可诱导T细胞增殖，激活Th1细胞因子反应并产生较高水平的IgG抗体，可引发伴有广泛斑块样脱髓鞘的复发缓解性中枢神经系统疾病，常用于诱导实验性自身免疫性脑脊髓炎（EAE）模型。