tetrahydrofolate

Trimethoprim (NSC-106568) 是抑菌抗生素，也是具有口服活性的二氢叶酸还原酶抑制剂。它对多种革兰氏阳性和革兰氏阴性需氧细菌具有活性，可用于尿路感染，肺孢子菌肺炎和志贺氏菌病的研究。

5-Methyltetrahydrofolate triglutamate is a form of folic acid.

Calcium N5-methyltetrahydrofolate (NSC-173328) 是左旋叶酸的钙盐，用于治疗心血管疾病、乳腺癌和结肠直肠癌。

10 FTHF disodium (10-Formyltetrahydrofolic acid disodium) 是四氢叶酸的一种形式，是合成代谢中的甲酰供体，参与合成嘌呤化合物。

5-Methyltetrahydrofolic acid (5-Methyl THF) 是四氢叶酸的甲基化衍生物，具有生物活性。5-Methyltetrahydrofolic acid 是主要的天然膳食叶酸，是血浆和脑脊液中叶酸的主要形式。

Methotrexate disodium 是一种叶酸类似物代谢抑制剂，具有免疫抑制剂和抗肿瘤特性，用于类风湿关节炎和研究多种癌症。

7-Hydroxymethotrexate 是 Methotrexate 主要的代谢产物。Methotrexate 对叶酸具有抑制作用，抑制二氢叶酸还原酶，从而防止叶酸转化为四氢叶酸，并抑制 DNA 合成。Methotrexate 对代谢也具有抑制作用。

5-Monobutyl methotrexate is an antineoplastic antimetabolite with immunosuppressant properties. It is a TETRAHYDROFOLATE DEHYDROGENASE inhibitor and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component

Aminopterin N-hydroxysuccinimide ester is an antineoplastic agent with immunosuppressive properties. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase. Its binding affinity for dihydrof

Emofolin sodium is the sodium salt of a synthetic antimetabolite analogue of folate with antineoplastic activity，which competes for the folate binding site of the enzyme dihydrofolate reductase, resulting in inhibition of tetrahydrofolate synthesis, deple

Pralatrexate, (R)- is a folate analog dihydrofolate reductase (DHFR) inhibitor exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively enters cells expressing RFC-1; intr

Pralatrexate, (S)- is a folate analog dihydrofolate reductase (DHFR) inhibitor exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively enters cells expressing RFC-1; intr

Levomefolate magnesium is the magnesium salt of the metabolite of folic acid (Vitamin B9) and it is a predominant active form of folate found in foods and in the blood circulation, accounting for 98% of folates in human plasma. It is transported across th

Tetrahydrofolic acid trihydrochloride (L-5,6,7,8-Tetrahydrofolic acid trihydrochloride) 是一种具有生物活性的维生素 B9 叶酸衍生物，是游离甲醛的受体，也是蘑菇酪氨酸酶的有效自杀底物，抑制甲基四氢叶酸介导的吲哚乙胺甲基化产生产物。

N-(4-Aminobenzoyl)-L-glutamic acid is an oxidation product and a metabolite of tetrahydrofolate.1Levels of N-(4-aminobenzoyl)-L-glutamic acid are increased in the plasma of mice fed a high folic acid-containing diet.2 1.Reed, L.S., and Archer, M.C.Oxidation of tetrahydrofolic acid by airJ. Agric. Food Chem.28(4)801-805(1980) 2.Burton, M.A., Antoun, E., Penailillo, R.S., et al.Folic acid induces intake-related changes in the mammary tissue transcriptome of C57BL/6 miceNutrients12(9)2821(2020)

Methotrexate di-n-butyl ester is an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofoltae dehydrogenase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.

Methotrexate diethyl ester is an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofoltae dehydrogenase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.

Sarcosine oxidase(SAO)，即肌氨酸氧化酶，可以催化肌氨酸的氧化去甲基化生成甘氨酸，H2O2, 5,10-CH2-四氢叶酸，常用于生化反应。

Aminopterin sodium is an antineoplastic agent with immunosuppressive properties. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase. Its binding affinity for dihydrofolate reductase effe