tachycardia

SB 203186 hydrochloride 是一种选择性的、竞争性的5-HT4拮抗剂。它拮抗5-HT4受体介导的多巴酚收缩大鼠离体食管弛缓，其在大鼠食管、豚鼠回肠和人类结肠的 pKB 值分别是 10.9、9.5 和 9.0。

Flecainide hydrochloride 是一种用于预防和治疗异常快速心率的药物。这包括室性和室上性心动过速。

Bunaftide（Bunaphtid）具有抗心律失常作用，对乌头碱诱导的室性心动过速有抑制作用。

Etripamil (MSP-2017) 是一种短效L 型钙通道拮抗剂，可用于治疗阵发性室上性心动过速的研究。它通过抑制房室结细胞中钙慢通道的钙离子流入，显示房室结传导并延长房室结不应期

Ripisartan (UP-269-6) 是一种强效的特异性血管紧张素 II 受体拮抗剂，对血管紧张素 II 介导的交感神经性心动过速反应有抑制作用。

Propoxur (Propoxure) 是一种氨基甲酸酯类杀虫剂，用于控制蟑螂、苍蝇、蚊子以及草坪和草坪昆虫。

Phenoxybenzamine hydrochloride (NCI-c01661) 是一种选择性的 α-adrenoceptor 和 calmodulin 的抑制剂，是常用的抗高血压药。

Lacidipine (SN-305) 是一种L 型钙离子通道阻断剂。

Ajmaline (Cardiorythmine) 是一种钠通道阻断剂，属于1A 类抗心律失常剂。Ajmaline 阻断 HERG 电流，在 HEK 细胞的 IC50为 1 μM，爪蟾卵母细胞的IC50为 42.3 μM。Ajmaline 在室性心动过速方面具有研究价值。

Aladorian (ARM036) is a benzothiazepine derivative and it has anti-arrhythmia effect. Aladorian is used for the research of heart failure and catecholaminergic polymorphic ventricular tachycardia[1][2].

(±)-Penbutolol ((Rac)-Penbutolol) 属于Penbutolol的外消旋体。作为一种β-肾上腺素受体拮抗剂，其具备口服活性。该化合物能有效抑制运动引起的心动过速，降低运动时的峰值呼气流量（PEFR）并在静息状态下减少肾素活性（PRA）。服用后1小时内，(±)-Penbutolol在血液中达到峰值浓度，半衰期为4.5小时，并转化为活性代谢物。该化合物常用于心血管病的相关研究。

YM-31636 (free base) 为具口服活性的高效选择性5-HT3受体激动剂，其pKi为9.67。该化合物可引起离体豚鼠远端结肠收缩，并在离体豚鼠右心房中诱导心动过速，拥有约0.23的相对内在活性。YM-31636 (free base) 有潜力应用于便秘研究领域。

Etripamil (MSP-2017) hydrochloride 是一种短效的 L-型钙通道拮抗剂，用于研究阵发性室上性心动过速 (PSVT)。它通过抑制钙离子慢通道来阻止钙离子流入，从而减缓房室结传导并延长房室结不应期。

Flecainide是一种口服的抗心律失常剂，是一种钠离子通道抑制剂和IKr抑制剂，用于治疗阵发性室上性心动过速（PSVTs）。

Disopyramide, a sodium channel blocker in the Class of 1a anti-arrhythmic agent, is used in the treatment of Ventricular Tachycardia. Disopyramide has a negative inotropic effect on the ventricular myocardium, resulting in a significant decrease in contra

VU0405601是KV11.1通道的高效药理激活剂，通过hERG激动作用保护心肌组织免受多非利特（Dofetilide）等hERG抑制剂诱发的心律失常与室性心动过速。

(3S)-hydroxy Quinidine is an active quinidine metabolite. Quinidine, an antiarrhythmic agent, undergoes rapid first-pass metabolism by the cytochrome P450 (CYP) isoforms CYP3A4, CYP2C9, CYP2E1, and CYP3A5, with CYP3A4 being the most active enzyme in the (3S)-hydroxy quinidine formation. (3S)-hydroxy Quinidine prolongs repolarization of canine Purkinje fibers in vitro and prevents ventricular fibrillation and ventricular tachycardia after coronary reperfusion in isolated rat hearts in a dose-dependent manner.

Ciprostene is the 9β-methyl analog of carbaprostacyclin and a stable analog of PGI2. Ciprostene exhibits biological activity similar to PGI2, but is 30-fold less potent. In patas monkeys, ciprostene induces hypotension and causes tachycardia when administered at a dose of 0.16 μg/kg/min. In addition, ciprostene inhibits ADP-induced platelet aggregation ex vivo and in vitro with ID50 values of 9.1 μg/kg/min and 60 ng/ml, respectively.

Ciprostene (free base) is a synthetic, chemically stable analog of prostacyclin (PGI2). In animal models, administration of ciprostene resulted in dose-dependent hypotension, tachycardia, and inhibition of ex vivo ADP-induced platelet aggregation. Ciprostene was evaluated in clinical trials in patients with peripheral vascular disease. It was found to reduce restenosis in patients with coronary artery disease undergoing therapeutic percutaneous transluminal coronary angioplasty.

Disopyramide HCl is the salt form of Disopyramide, an antiarrhythmic medication used in the treatment of ventricular tachycardia. It is a sodium channel blocker and therefore classified as a Class 1a anti-arrhythmic agent. Disopyramide has a negative inotropic effect on the ventricular myocardium, significantly decreasing the contractility. Disopyramide also has an anticholinergic effect on the heart which accounts for many adverse side effects. Disopyramide is available in both oral and intravenous forms, and has a low degree of toxicity.

Fadolmidine, also known as MPV-2426, is a novel and potent alpha2 -adrenoceptor (alpha2) -AR) agonist developed for spinal analgesia. Fadolmidine displayed high affinity and full agonist efficacy at all three human alpha2-adrenoceptor subtypes (A, B and C) in transfected CHO cells with EC50 values (nM) of 0.4, 4.9 and 0.5, respectively. Fadolmidine inhibited also electrically evoked contractions in rat vas deferens demonstrating the activation of rodent presynaptic alpha2D-adrenoceptors with an EC50 value of 6.4 nM. Moreover, fadolmidine was a full agonist at human alpha1A-adrenoreceptor (EC50 value 22 nM) and alpha1B-adrenoreceptor (EC50 value 3.4 nM) in human LNCaP cells and transfected HEK cells, respectively. Agonism at the alpha1-adrenoceptor was also observed in rat vas deferens preparations although at lower potency (EC50 value 5.6 microM). Fadolmidine demonstrated potent alpha2-adrenoceptor agonist activity also in vivo by inhibiting electrically induced tachycardia i......

Urocortin II, a neuropeptide hormone within the corticotropin-releasing factor (CRF) family—which comprises mammalian CRF, urocortin I, urocortin III, frog sauvagine, and piscine urotensin I—displays 34, 43, and 37-40% sequence homology with rat and human CRF, human urocortin I, and human urocortin III, respectively. This compound enhances rabbit ventricular myocyte shortening and relaxation in both a time- and concentration-dependent manner. In vivo studies reveal that urocortin II lowers arterial blood pressure in both normotensive and spontaneously hypertensive rats through peripheral CRF2 receptor agonism, inducing dose-dependent tachycardia and hypotension at doses of 3 and 30 pmol/kg. Additionally, it mitigates the visceral pain response to colorectal distension at 10 and 20 μg/kg in conscious rats and delays gastric emptying in mice.

L-706000 (MK 499) free base 作为一种 III 类抗心律失常剂，它是一种高效的 hERG 通道阻滞剂，其 IC50 仅为 32 nM。此化合物主要用于恶性室性心动过速的研究。

REGN-7544是一种靶向NPR1的人源化单克隆抗体，能够阻断和抑制NPR1从而升高血压，可用于研究低血压，脓毒性休克和体位性心动过速综合征。