stomach cancer

PFK-015 (PFK15) 是一种有效的 PFKFB3 抑制剂，对重组PFKFB3的IC50为110 nM。它能抑制 Y 细胞中的 PFKFB3 活性，IC50为20 nM。

HRO761是一种有效的 Werne r 综合征 RecQ DNA 解旋酶 (WRN) 抑制剂，可用研究像结肠癌和胃癌等癌症。

Nizatidine (Acinon) 是一种竞争性和可逆的组胺 H2 受体拮抗剂，具有抗酸活性，可用于胃溃疡的研究。

AZ1508, a tubulin inhibitor[1], serves as a drug-linker conjugate for antibody-drug conjugates (ADC) targeting breast and stomach cancer treatment.

HC-5404-Fu 是一种具有抗肿瘤活性的PERK抑制剂，能够抑制内质网应激反应的信号通路。该化合物增强了肾细胞癌细胞对血管内皮生长因子 (VEGF) 受体酪氨酸激酶抑制剂 (TKIs) 的敏感性。HC-5404-Fu 视为潜在的治疗选项，可用于研究肾细胞癌、胃癌、转移性乳腺癌、小细胞肺癌及其他实体肿瘤。

Pericosine A is a fungal metabolite that has been found inP. byssoidesand has anticancer activity.1It inhibits the growth of a variety of cancer cells, including breast, colon, lung, ovary, stomach, and prostate cell lines (GI50s = 0.05-24.55 μM) and increases survival in a P388 mouse xenograft model when administered at a dose of 25 mg/kg. Pericosine A inhibits EGFR by 40 to 70% when used at a concentration of 100 μg/ml. It also reacts with organosulfur compounds in skunk spray to form stable thioethers as odorless products.2 1.Yamada, T., Iritani, M., Ohishi, H., et al.Pericosines, antitumour metabolites from the sea hare-derived fungus Periconia byssoides. Structures and biological activitiesOrg. Biomol. Chem.5(24)3979-3986(2007) 2.Du, L., Munteanu, C., King, J.B., et al.An electrophilic natural product provides a safe and robust odor neutralization approach to counteract malodorous organosulfur metabolites encountered in skunk sprayJ. Nat. Prod.82(7)1989-1999(2019)

Albendazole-D7 is intended for use as an internal standard for the quantification of albendazole by GC- or LC-MS. Albendazole (T1152) is an orally bioavailable benzimidazole anthelmintic that is active against a variety of helminths,including liver flukes,tapeworms,and roundworms. It eliminates Trichostrongylus in the fourth stomach of cattle and sheep when orally administered at doses ranging from 2.5 to 10 mg/kg as well as other species in the fourth stomach and the small and large intestine. Albendazole (T1152) (0.05% in the diet)protects mice against lethal infection with A. suum larvae. It also inhibits growth of HT-29 human colorectal cancer cells (IC50 = 0.12 µM),halts the cell cycle at the G2/M phase,and induces apoptosis. In an HT-29 mouse xenograft model,it inhibits peritoneal tumor growth when administered intraperitoneally at a dose of 150 mg/kg but not when administered orally. Albendazole (T1152)inhibits mammalian tubulin polymerization and inhibits binding of [3H]mebendazole t......

ABT-751 (E7010) hydrochloride 为一种新型磺胺类抗有丝分裂化合物及微管蛋白(tubulin)结合剂,具有高口服生物利用度.该化合物通过与β-微管蛋白的秋水仙碱位点结合,阻断微管蛋白的聚集,从而在G2/M期引起细胞周期阻滞并诱导细胞凋亡(apoptosis).此外,ABT-751 (E7010) hydrochloride 还能通过抑制AKT/MTOR信号通路,促进细胞自噬(autophagy).该化合物对包括肺癌、胃癌、结肠癌和乳腺癌在内的多种癌细胞类型展示出显著的抑制效果.

2,3-Dihydro-3α-methoxynimbolide induces apoptosis via both mitochondrial and death receptor pathways in stomach (AZ521) cancer cell line.