sn-6

SN 6 (SN6) 是选择性NCX 抑制剂，可抑制 NCX1、NCX2 和 NCX3 对45Ca2+的吸收，IC50值分别为 2.9、16 和 8.6 μM。

PSN632408 is an optimized agonist of GPR119 receptors that display similar potency to OEA at both recombinant mouse and human GPR119 receptors (EC50: 5.6 and 7.9 uM, respectively).

S-N6-Methyladenosylhomocysteine (Chart 1-1) 是高效的组蛋白甲基转移酶DOT1L (histone methyltransferase DOT1L) 抑制剂，其IC50为0.29 μM，在癌症研究中具有重要作用。

CGS 22652 has thromboxane receptor antagonism combined with thromboxane synthase inhibition.

CL2 Linker is a cleavableADC linker. CL2-SN-38 and CL2A-SN-38 are equivalent in drug substitution (~6), cell binding (Kd ~1.2 nM), cytotoxicity (IC50 ~2.2 nM), and serum stability in vitro (t1/2 ~20 hours)[1][2].

06:0 PE (PE(6:0/6:0)) 是一种具有短酰基链的水溶性磷脂，其特点是具有抗肿瘤活性和能够抑制肿瘤在体内的发展。此外，它还展现出抗增殖和促进细胞凋亡的功能，并可作为磷脂酰胆碱与磷脂酰乙醇胺的前体。

1-1(Z)-Octadecenyl-2-docosahexaenoyl-sn-glycero-3-PE (18:0p/22:6-PE) 为一种通过质谱成像技术在大鼠脑组织中确认的独特结构脂质，此方法可准确识别其不同脂肪酸链的异构体及其分布。

1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-phosphoethanolamine（18:0-22:6 PE）是一种用于构建脂质体的关键脂质成分。脂质体以其同心磷脂双层膜结构主要用于抗癌和抗感染的药物递送系统中。该化合物能够在其水性内部空间包裹高极性水溶性药物，同时将亲脂药物整合入脂质双层。它尤其适用于递送反义寡核苷酸，有效解决细胞内吸收不足和药物体内迅速丢失的问题。

1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA 是一种含有花生四烯酸的磷脂，作用于sn-1位置，作为1-Monoarachidin的前体。该化合物可以结合LPA2/EDG4受体，抑制LPS刺激下野生型树突状细胞分泌TNF-α和IL-6，而对Lpa2-/-树突状细胞无影响。此外，它在丁酸钠存在下能减少HT-29人结肠癌细胞向杯状细胞的分化。

1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA (sodium) (1-Arachidonoyl-sn-glycerol 3-phosphate (sodium)) 是一种含有花生四烯酸的磷脂，能够与LPA2/EDG4受体结合 (EC50为10 nM)。该化合物在大鼠脑中占含花生四烯酸溶血磷脂酸种类的37%，并作为1-花生四烯酰甘油的前体。它能够抑制野生型LPS刺激的树突状细胞分泌TNF-α和IL-6。此外，在存在丁酸钠时，1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA (sodium) 可抑制HT-29结肠癌细胞的杯状细胞分化。

LEI-106是一种有效的DAGL-α(sn-1-Diacylglycerol lipase α)/ABHD6（α/β-hydrolase domain 6）双重抑制剂，Ki值分别为 0.7和0.8 μM，可用于研究肥胖和代谢综合征。

1-Arachidonoyl lysophosphatidic acid is a phospholipid containing arachidonic acid at the sn-1 position. It has been found in rat brain as 37% of the arachidonic acid-containing lysophosphatidic acid (LPA) species and is a precursor to 1-arachidonoyl glycerol . 1-Arachidonoyl lysophosphatidic acid binds to the LPA2/EDG4 receptor with an EC50 value of approximately 10 nM. It prevents TNF-α and IL-6 secretion in wild-type but not Lpa2-/- dendritic cells stimulated by LPS. It also decreases differentiation of HT-29 human colon carcinoma cells to goblet cells in the presence of sodium butyrate.

1,2,3-Trioctanoyl-rac-glycerol-13C3 is intended for use as an internal standard for the quantification of 1,2,3-trioctanoyl-rac-glycerol by GC- or LC-MS. 1,2,3-Trioctanoyl-rac-glycerol is a triacylglycerol that contains octanoic acid at the sn-1, sn-2, and sn-3 positions. Dietary administration of 1,2,3-trioctanoyl-rac-glycerol increases hippocampal levels of the glycolytic metabolites glucose 6-phosphate, fructose 6-phosphate, and β-hydroxybutyrate and the seizure threshold in the 6 Hz psychomotor seizure test in mice.1 Formulations containing 1,2,3-trioctanoyl-rac-glycerol have been used in cosmetic products as thickening and skin-conditioning agents.

(R)-KT109 is the (R) isomer of the diacylglycerol lipase β (DAGLβ) inhibitor KT109 . (R)-KT109 is an inhibitor of DAGLβ (IC50 = 0.79 nM) and of DAGLα-mediated hydrolysis of 1-stearoyl-2-arachidonoyl-sn-glycerol . It also inhibits α/β-hydrolase domain-containing protein 6 (ABHD6) with an IC50 value of 2.51 nM. (R)-KT109 is more potent at DAGLβ, DAGLα, and ABHD6 than (S)-KT109 .

(S)-KT109 is the (S) isomer of the diacylglycerol lipase β (DAGLβ) inhibitor KT109 . (S)-KT109 is a less potent inhibitor of DAGLβ (IC50 = 39.81 nM), DAGLα-mediated hydrolysis of 1-stearoyl-2-arachidonoyl-sn-glycerol (IC50 = 794.3 nM), and α/β-hydrolase domain-containing protein 6 (ABHD6; IC50 = 630.9 nM) than (R)-KT109 .

18:0-22:6 DG (1-Stearoyl-2-docosahexaenoyl-sn-glycerol) 是一种二酰基甘油，可以与RasGRP 结合并调节MAP 激酶活化。

1,2,3-Tri-6(Z)-octadecenoyl glycerol, a triacylglycerol, incorporates 6(Z)-octadecenoic acid (cis-petroselinic acid) into the sn-1, sn-2, and sn-3 positions. This compound is prevalent in plant seed oils.

Irinotecan-d10 Hydrochloride 是 Irinotecan Hydrochloride 的氘代化合物。Irinotecan Hydrochloride 的 CAS 号为 100286-90-6。Irinotecan Hydrochloride 是喜树碱半合成衍生物的盐酸盐，是一种拓扑异构酶 I 抑制剂，可研究结肠癌和直肠癌。

(2R)-O-[4-(3"-Hydroxypropyl)-2,6-dimethoxyphenyl]-3-O-β-Dglucopyranosyl-sn-glycerol (compound 6) 作为一种甘油糖苷，可以从冷水花属 (genusPilea) 的整株植物中提取。

12-Dipalmitoyl-3-Linoelaidoyl-rac-glycerol 是一种三酰基甘油，含有两个 sn-1 和 sn-2 位的 Palmitic acid 和一个 sn-3 位的 Linolelaidic acid。Palmitic acid 是一种广泛存在于动植物中的长链饱和脂肪酸，可诱导小鼠颗粒细胞中葡萄糖调节蛋白 78 (GRP78) 和 CCAAT/增强子结合蛋白同源蛋白 (CHOP) 的表达。而 Linolelaidic acid 是一种 omega-6 反式脂肪酸 (TFA)，作为一种能量来源和必需营养素，可添加于肠内、肠胃外和婴儿配方食品，并用于心脏病研究。