ro-51

dual P2X3 and P2X2 3 antagonist

2-chloro-5-(16,18-dioxo-17-azapentacyclo[6.6.5.0~2,7~.0~9,14~.0~15,19~]nonadeca-2,4,6,9,11,13-hexaen-17-yl)benzoic acid 可用于合成多种有机化合物。

Ro 5126766 (CH5126766) 是双重MEK RAF 抑制剂，抑制BRAFV600E、CRAF、MEK 和 BRAF，IC50分别为 8.2、56、160 和 190 nM。

RO5166017 是一种具有口服活性、高效性和选择性的痕量胺相关受体 1（TAAR1）激动剂，可用于研究条件性味觉厌恶额神经障碍。

RO5126946 is a Novel α7 nicotinic acetylcholine receptor-positive allosteric modulator. RO5126946 allosterically modulates α7nAChR activity. RO5126946 increased acetylcholine-evoked peak current and delayed current decay but did not affect the recovery of α7nAChRs from desensitization. In addition, RO5126946's effects were absent when nicotine-evoked currents were completely blocked by coapplication of the α7nAChR-selective antagonist methyl-lycaconitine.

FCE-24379 is a selective antagonist of vascular serotonin receptors that has been shown to lowers blood pressure in hypertensive rats.

Danoprevir (RG7227) 是具有口服活性的NS3 4A 蛋白酶抑制剂，IC50值为 0.29 nM。它抑制 HCV 基因型 1a, 1b, 4, 5, 6 (IC50s=0.2-0.4 nM) 和 2b, 3a (IC50s=1.6, 3.5 nM)。它也是SARS-CoV 3CLpro 的抑制剂，IC50为 0.05 μM。

RO5101576 is a potent antagonist of LTB4 receptor.

Avutometinib potassium is a MEK inhibitor (MEKi) that enhanced the inhibition of pseudovirus infection by GLPG-0187. It Blocks SARS-CoV-2 Delta and Omicron Pseudovirus Infection of Airway Epithelial Cells In Vitro, Which Could Attenuate Disease Severity