resveratrol analog

Resveratrol analog 2 is an analog of Resveratrol. Resveratrol is a natural polyphenolic phytoalexin with possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties.

Resveratrol analog 1 是天然产物白藜芦醇的类似物，具有比白藜芦醇更显著的抗白血病活性。

Rhapontigenin (Protigenin) 是一种基于机制的选择性细胞色素 P450 1A1 (IC50: 400 nM) 灭活剂。它是一种芳烃羟化酶，可激活作为致癌物质的多环芳烃。它是白藜芦醇的天然类似物，具有抗癌，抗氧化剂，抗真菌和抗菌活性。

Isorhapontigenin (Isorhapotogenin) 是一种从中草药闭苞买麻藤中分离出的膳食多酚，诱导自噬并抑制浸润性膀胱癌的形成，有抗炎作用。

NQO2-IN-1是一种白藜芦醇（resveratrol）类似物，是有效的醌氧化还原酶2（NQO2）抑制剂（IC50=95 nM），通过产生ROS和上调DR5（death receptor 5）逆转trial耐药性并促进细胞凋亡，具有抗肿瘤的潜力。

4-Hydroxyresveratrol (3,4,5,4'-Tetrahydroxystibene) 是白藜芦醇的类似物，能够在不同程度上诱导促凋亡的p53 Bax基因表达。该化合物可以诱导SV40病毒转化的WI38细胞 (WI38VA) 发生凋亡，但对WI38细胞没有类似效果。此外，4-Hydroxyresveratrol 能显著提升WI38VA细胞中p53、GADD45和Bax基因的表达，并同时抑制bcl-2基因的表达。

trans-Trimethoxyresveratrol (MR-3) 是一种 Resveratrol(RSV) 的衍生物，与Resveratrol(RSV)相比，它可能是一个更有效的抗炎、抗血管新生的化合物。

The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 μM compared to 20 μM by resveratrol.

Azo-Resveratrol is an analog of Resveratrol used as a potent tyrosinase inhibitor.