Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Mitoquidone 是一种新型的五环吡咯醌,是一种潜在的抗癌剂。Mitoquidone 在一系列实验性实体肿瘤模型中表现出良好的活性且不表现出明显的细胞毒性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 610 | 现货 | ||
5 mg | ¥ 1,430 | 现货 | ||
10 mg | ¥ 2,150 | 现货 | ||
25 mg | ¥ 3,630 | 现货 | ||
50 mg | ¥ 5,230 | 现货 | ||
100 mg | ¥ 7,390 | 现货 | ||
500 mg | ¥ 14,800 | 现货 |
产品描述 | Mitoquidone, a novel pentacyclic pyrroloquinone, is a potential anticancer agent. Mitoquidone showed good activity in a range of experimental solid tumour models and did not exhibit significant cytotoxicity. |
体内活性 | Mitoquidone (MTQ) demonstrated good activity in a range of experimental solid tumour models, but was weakly active against standard prescreens such as the P388 murine leukaemia. Twenty-seven patients were treated with MTQ given as a 4-h infusion either once every 21 days (150-600 mg/m2), once a week (200 mg/m2 per week), or as 5 daily doses repeated every 28 days (60-180 mg/m2 per day). Temporary remission of B-symptoms occurred in two patients with lymphoma. Linear pharmacokinetics were observed with a terminal plasma half-life of 2.9 +/- 2.1 h (n = 18 doses). The volume of distribution was 3.4 +/- 2.6 l/kg and plasma clearance was 629 +/- 469 ml/min per m2.[1] |
分子量 | 299.32 |
分子式 | C20H13NO2 |
CAS No. | 91753-07-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: < 1mg/ml (insoluble)
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Mitoquidone 91753-07-0 Others Inhibitor inhibitor inhibit