npy y2 antagonist

SF-22 是一种可透过血脑屏障的神经肽 Y 受体(Y2R) 拮抗剂，具有潜在抗炎活性，可用于研究神经系统紊乱带来的疾病。

CYM 9484 is a selective and potent neuropeptide Y (NPY) Y2 receptor antagonist with IC50 value of 19 nM.

BIIE-0246 is a potent and highly selective non-peptide neuropeptide Y (NPY) Y2 receptor antagonist. With an IC50 of 15 nM.

Y2 Antagonist 36 is a highly potent, soluble and selective antagonist of NPY Y2.

Potent, selective and competitive nonpeptide antagonist for the neuropeptide Y Y2 receptor (IC50 = 15 nM). Displays > 650-fold selectivity for NPY Y2 over Y1, Y4 and Y5 receptors. Active in vivo.

BIBP 3226 trifluoroacetate is a mixed non-peptide neuropeptide Y Y1(NPY Y1) and neuropeptide FF (NPFF) receptor antagonist (Kivalues are 1.1, 79, 108, > 1000, > 1000 and >1000 for rNPY Y1, hNPFF2, rNPFF, rNPY Y2, rNPY Y4and rNPY Y5respectively). Produces an anxiogenic-like effect in rats following i.c.v. administration.

Y2-Antagonist-2 is a novel, selective, soluble non-​peptidic NPY Y2 receptor antagonist with enhanced CNS exposure.