npr1

Isosorbide dinitrate (Isordil) 是 NO 供体，可预防心肌梗死 (MI) 引起的左室重构及心功能退化。

Acibenzolar-S-methyl is a fungicide. Acibenzolar-S-methyl works by activating a plant's own defense system by increasing the transcription of W-box controlled genes such as CAD1, NPR1, and PR2.

AP 811, a selective antagonist of the atrial natriuretic peptide clearance receptor (APN-CR, NPR3) with a K i value of 0.48 nM, exhibits remarkable selectivity for NPR3 over NPR1 by more than 20,000-fold. Moreover, AP 811 effectively eliminates ANP-induced pump stimulation.

AP 811 acetate是一款选择性的ANP-CR（即NPR3）拮抗剂，其Ki值为0.48 nM。该化合物对NPR3的选择性是对NPR1的两万倍。此外，AP 811 acetate能够消除ANP诱导的泵激活现象。

JS11 是一种针对利钠多肽受体 1 (Npr1) 的抑制剂,具有对hNpr1 的IC50 值为 1.9 μM.在小鼠模型中,JS11 能有效改善瘙痒症状.

Vixticibart，一种IgG4κ型人源抗体，靶向NPR1。其同型对照为HumanIgG4(S228P) kappa, Isotype Control。

Imelciment 为针对 NPR1 的 half-Ig G4-κ h-CH2-CH3 类型人源化抗体。