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TargetMol产品目录中 "

notch3

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  • 抑制剂&激动剂
    5
    TargetMol | Inhibitors_Agonists
  • 重组蛋白
    4
    TargetMol | Recombinant_Protein
  • BMS-906024
    Osugacestat, AL-101, BM-0018
    T146801401066-79-2In house
    BMS-906024 (Osugacestat) 是一种可口服且具有选择性的γ 分泌酶抑制剂,是一种小分子 Notch 抑制剂。BMS-906024 对多种人类癌症异种移植具有广谱抗肿瘤活性。BMS-906024 可阻止所有四种 Notch 受体的激活,对 Notch1、-2、-3 和 -4 受体的 IC50 分别为 1.6、0.7、3.4 和 2.9 nM。
    • ¥ 3980
    In stock
    规格
    数量
  • NSC 405020
    T18917497-07-6
    NSC 405020 是一种 MT1-MMP 的非催化抑制剂,可特异地靶向 MT1-MMP 的 PEX 结构域,不会抑制 MT1-MMP 和 MMP-2的催化活性。
    • ¥ 115
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • Notch inhibitor 1
    T163411584647-27-7
    Notch inhibitor 1 is an effective Notch inhibitor (IC50s: 7.8 and 8.5 nM for Notch 1 and Notch 3, respectively). Notch inhibitor 1 is also used in the research of cancer.
    • 待询
    3-6月
    规格
    数量
  • S2157
    S2157
    T397992262488-39-9
    S2157, a potent N-alkylated tranylcypromine (TCP) derivative lysine-specific demethylase 1 (LSD1) inhibitor, enhances H3K9 methylation and concurrently reduces H3K27 acetylation at super-enhancer sites. This compound triggers apoptosis in TCP-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells by inhibiting NOTCH3 and TAL1 gene expression. Moreover, S2157 is capable of crossing the blood-brain barrier, effectively eliminating central nervous system (CNS) leukemia in mice models implanted with T-ALL cells.
    • ¥ 3770
    5日内发货
    规格
    数量
  • S2116
    T398002262489-89-2
    S2116 is a powerful inhibitor of lysine-specific demethylase 1 (LSD1), and it is a derivative of N-alkylated tranylcypromine (TCP). S2116 exhibits its inhibitory effects by increasing H3K9 methylation and inducing reciprocal H3K27 deacetylation at super-enhancer regions. In TCP-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells, S2116 triggers apoptosis by repressing the transcription of NOTCH3 and TAL1 genes. Furthermore, S2116 demonstrates significant growth retardation of T-ALL cells when xenotransplanted into mice.
    • ¥ 4150
    5日内发货
    规格
    数量