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Anti-NOTCH3 Antibody (7P604)

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货号 TMAB-09571

Anti-NOTCH3 Antibody (7P604) 是一种 Mouse 抗体，靶向 NOTCH3。Anti-NOTCH3 Antibody (7P604) 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-NOTCH3 Antibody (7P604)

Anti-NOTCH3 Antibody (7P604)

一键复制产品信息
Rating icon 还可以
货号 TMAB-09571

Anti-NOTCH3 Antibody (7P604) 是一种 Mouse 抗体，靶向 NOTCH3。Anti-NOTCH3 Antibody (7P604) 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,560
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-NOTCH3 Antibody (7P604) is a Mouse antibody targeting NOTCH3. Anti-NOTCH3 Antibody (7P604) can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
克隆号
7P604
反应种属
Human
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:200-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Monoclonal
宿主来源Mouse
亚细胞定位Cell membrane; Single-pass type I membrane protein. Notch 3 intracellular domain: Nucleus. Note=Following proteolytical processing NICD is translocated to the nucleus.
组织特异性Ubiquitously expressed in fetal and adult tissues.
构建方式Hybridoma Monoclonal Antibody
纯化方式Protein G purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008]
抗原信息
免疫原
KLH conjugated synthetic peptide: human NOTCH3
抗原种属
Human
基因名称
NOTCH3
基因ID
4854
蛋白名称
Neurogenic locus notch homolog protein 3
Uniprot ID
Q9UM47
功能
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs.
化学信息
分子量Theoretical: 255 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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