netupitant

Netupitant (CID 6451149) 是一种高效选择性、可口服的神经激肽 1 受体 (NK1) 拮抗剂，具有止吐作用，在 CHO 细胞中对 hNK1的 Ki 值为 0.95 nM。

Netupitant D6 is the deuterium labeled Netupitant, which is a selective and orally active antagonist of neurokinin-1 receptor.

Monohydroxy Netupitant is a highly selective antagonist of NK1 receptor, and is Netupitant metabolite.

Netupitant N-oxide is a highly selective antagonist of NK1 receptor, is Netupitant metabolite.

Monohydroxy Netupitant D6 is a metabolite of Netupitant.

N-desmethyl Netupitant D6 is the deuterium labeled N-desmethyl Netupitant, which is a Netupitant metabolite.

Netupitant N-oxide D6 is a Netupitant metabolite, is the deuterium labeled Netupitant N-oxide.

Netupitant N-oxide (3)-d6 是 Netupitant N-oxide (3) 的氘代化合物。Netupitant N-oxide (3) 的 CAS 号为 910808-11-6。

N-desmethyl Netupitant是 Netupitant 的代谢物，是一种潜在的 Substance-P 受体激动剂，可用于研究心血管疾病和神经系统疾病。

Fosnetupitant is a methylene phosphate prodrug of Netupitant. It has a pKi of 9.5 for the human NK1 receptor.

Fosnetupitant chloride monohydrochloride（Pronetupitant chloride monohydrochloride）为NK1受体拮抗剂，对人NK1受体和NK3受体的pKi分别为9.5和6.1。它是奈妥匹坦的亚甲基磷酸酯前体。

6-(4-methylpiperazin-1-yl)-4-o-tolylnicotinamide 可用于合成befetupitant 和netupitant。