neomycin

Neomycin (free base) is an antibiotic complex produced by Streptomyces fradiae. It is composed of neomycins A, B, and C. It acts by inhibiting translation during protein synthesis.

Neomycin sulfate (Framycin sulfate) 是一种广谱的氨基糖苷类抗生素。Neomycin sulfate 可以阻断细菌蛋白质的合成以发挥抗菌活性。Neomycin sulfate 常用于筛选具有 Neo 抗性基因的原核和真核细胞。

Framycetin sulfate (Neomycin Sulphate B) 是一种氨基糖苷类抗生素，是 RNase P 裂解活性抑制剂，Ki 为 35 μM。它抑制锤头状核酶，Ki 值为 13.5 μM，可用于肝性脑病和肠致病性大肠杆菌感染的研究。

Neomycin C是新霉素复合物中的两个主要活性异构体之一，为含2-DOS的氨基糖苷复合物，包括neomycin A，neomycin B以及neomycin C。其活性仅为Neomycin B的一半。

Framycetin is an aminoglycoside antibiotic and it also inhibits hammerhead ribozyme (Ki: 13.5 μM).

Vineomycin A1 (OS-4742 A1) 是一种抗革兰氏阳性菌的抗生素，来源于Streptomyces matensissubsp.vineus。此外，Vineomycin A1 在小鼠实验中展现了抗肿瘤活性，并有望应用于皮肤纤维化的研究。

Streptonigrin is a natural product produced by Streptomyces flocculus, has both anti-tumor and anti-bacterial activity. Streptonigrin acts as a pan-PAD inhibitor (IC50s: 48.3±34.2 µM, 26.1±0.3 µM, 0.43±0.03 µM, and 2.5±0.4 µM for PAD1, PAD2, PAD3, and PAD

Carbazomycin C is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities. It is active against S. aureus, B. anthracis, B. subtilis, and M. flavus, the fungi T. asteroides and T. mentagrophytes, and P. falciparum. It is also active against a panel of five plant pathogenic fungi. Carbazomycin C is cytotoxic to MCF-7, KB, and NCI H187 cells. It also inhibits 5-lipoxygenase (5-LO) activity in RBL-1 cell extracts.

Paromomycin Sulfate (Aminosidine sulfate) 是一种广谱氨基糖苷类抗生素 ，是具有杀螨杀菌作用的新霉素衍生物。它通过与细菌 30S 核糖体 A 位点的 RNA 寡核苷酸特异性结合，使 mRNA 的翻译提前终止，并抑制蛋白质合成。它可研究细菌和寄生虫感染。

DMEA-PNU-159682 (molecule D12) is an ADC cytotoxin molecule that includes neomycin (MMDX) metabolites from liver microsomes and the effective ADC cytotoxin PNU-159682.

PNU-159682 是蒽环类新霉素的代谢产物，是一种 DNA 拓扑异构酶 II 抑制剂，具有出色的细胞毒性。

Paromomycin (Sulfate Salt) is an aminoglycoside that is active against Gram-negative and many Gram-positive bacteria as well as some protozoa and cestodes. Paromomycin in combination with sodium stibogluconate has proven to be effective in African and Indian VL (visceral leishmaniasis) and improves survival in African VL[3]. PS (Paromomycin Sulfate) is effective for elimination of B. coli without hematological side effects[4]. The activity of phosphoglucose isomerase was slightly inhibited by 10(-3) M paromomycin sulfate while those of hexokinase, phosphofructokinase and glucose-6-phosphate dehydrogenase were not inhibited[5]. In addition, with regard to correlation of endotoxemia with renal impairment, endogenous creatinine clearance and p-aminohippurate clearance were significantly improved (P less than 0.02) in those patients whose endotoxemia disappeared on paromomycin sulfate administration. Paromomycin sulfate seems to be effective in the prevention of endotoxemia and the associated renal impairment in cirrhosis in man[6]. Significantly higher frequencies of resistance to paromomycin, kanamycin, neomycin and tobramycin were observed in S. aureus isolates from PS (paromomycin supplemented) birds. Paromomycin supplementation resulted in resistance to aminoglycosides in bacteria of PS turkeys. Co-selection for resistance to other antimicrobial agents was observed in E. coli isolates[7].

Neamine，新霉素降解产物，为广谱氨基糖苷类抗生素。作为抗血管生成剂，针对血管生成素 (angiogenin)，展现抗菌、抗肿瘤及神经保护活性。

BDM88855 hydrochloride 作为同源AcrB蛋白的变构抑制剂，能够提升多种抗生素（例如：苯唑西林、利奈唑胺、新生霉素）对野生型大肠杆菌的抗菌效果。

BDM88855 作为同源AcrB蛋白的变构抑制剂，能够提升多种抗生素（例如：苯唑西林、利奈唑胺、新生霉素）针对野生型大肠杆菌的抗菌效果。