nebivolol

Nebivolol, a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect, is used in treatment of hypertension, in Europe, it is also used for left ventricular failure. It is highly cardioselective under certain circumstances.

Nebivolol hydrochloride (R 065824 hydrochloride) 是一种β1-肾上腺素受体选择性抑制剂，IC50为0.8 nM。

(Rac)-Nebivolol ((Rac)-R 065824) 是 Nebivolol 的外消旋异构体。Nebivolol 是一种选择性的β1 肾上腺素能受体拮抗剂（IC50= 0.8 nM）。Nebivolol 显示血管舒张活性。在乙醇引起心脏毒性的早期阶段，Nebivolol 能预防 Nox2 NADPH 氧化酶上调和脂质过氧化。

4-Hydroxy Nebivolol, a primary metabolite of Nebivolol, results from the enzymatic hydroxylation of Nebivolol by the cytochrome P450 (CYP) isoform CYP2D6.

N-Nitroso nebivolol (mixture of diastereomers) 属于亚硝胺类化合物,展现出诱变活性.

Nebivolol hydrochloride (Standard) 是 Nebivolol hydrochloride 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Nebivolol hydrochloride (R 065824 hydrochloride) 是一种β1-肾上腺素受体选择性抑制剂，IC50为0.8 nM。

Dexnebivolol ( R67138) is an antagonist of the ß-adrenergic receptor and is an enantiomer of Nebivolol. Nebivolol is a β1 receptor blocker with nitric oxide enhancing vasodilation effect.

Levonebivolol (R 67145) is an enantiomer of nepirolol, a β1 blocker with nitric oxide vasodilators for the treatment of hypertension.