mpo-in-1

MPO-IN-1 是一种具有口服活性的髓过氧化物酶 (MPO) 抑制剂，抑制 MPO 和甲状腺过氧化物 (TPO)，可用于研究炎症。

SNT-8370 是一种口服活性抑制剂，针对VAP-1 (IC50: 10 nM) 和髓过氧化物酶 (MPO) (IC50: 17 nM) 的抑制效力比其他哺乳动物过氧化物酶高100-1000倍。SNT-8370 能有效抑制MPO介导的LDL脂质过氧化以及急性炎症肺损伤模型中的白细胞浸润。作为一种抗炎化合物，SNT-8370 适用于炎症性疾病的研究。

2-chloro Palmitic acid is a monochlorinated form of palmitic acid . It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate . 2-chloro Palmitic acid (10 μM) induces neutrophil extracellular trap (NET) formation (NETosis) in human neutrophils, increasing DNA release from neutrophils, colocalization of MPO with extracellular DNA (ecDNA), and trapping of E. coli. It increases COX-2 protein levels in human coronary artery endothelial cells (HCAECs) when used at a concentration of 50 μM and increases production of P-selectin, von Willebrand factor, and angiopoietin-2 in HCAECs, as well as neutrophil and platelet adherence, when used at a concentration of 10 μM. 2-chloro Palmitic acid (10-50 μM) also induces apoptosis in THP-1 cells and primary human monocytes and increases caspase-3 activity in THP-1 cells.

Olsalazine-13C6 is intended for use as an internal standard for the quantification of olsalazine by GC- or LC-MS. Olsalazine (T20615) is an orally bioavailable prodrug form of the anti-inflammatory agent 5-aminosalicylic acid that is cleaved by bacterial azo reductases in the gut to generate active 5-ASA.1

MPO-IN-4 (compound 12) 是一种有效的选择性髓过氧化物酶 (MPO) 抑制剂，IC50为 25 nM。MPO-IN-4对甲状腺过氧化物酶(TPO)也显示抑制作用，IC50为2.2 μM。MPO-IN-4 对甲基鸟嘌呤甲基转移酶 (MGMT) 没有影响。

COX-2-IN-14 (compound 2a) is a highly potent and selective inhibitor of COX-2 (cyclooxygenase-2), with strong binding affinity at the active site of COX-2 co-crystal. Demonstrating remarkable in vivo anti-inflammatory activity, COX-2-IN-14 effectively reduces ear edema and myeloperoxidase (MPO) activity in mice [1].

MPO-IN-5 是一种有效的、不可逆的 MPO (髓过氧化物酶) 抑制剂。MPO-IN-5 能够抑制 MPO 过氧化作用 (IC50: 0.22 μM)，也能够抑制 hERG 结合 (IC50: 2.8 μM)。MPO-IN-5 显示出快速的抑制动力学，酶失活率 (kinact/Ki) 为 23000 M 1s 1。

Bivalirudin TFA 是20个氨基多肽，可逆地抑制凝血酶。