kir 103

KIR2DL4 Protein, Human, Recombinant (hFc) is expressed in CHO mammalian cells with hFc tag. The predicted molecular weight is 54.4 kDa and the accession number is ADY38409.1.

KIR2DL4 Protein, Human, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 50.3 kDa and the accession number is ADY38409.1.

Killer cell immunoglobulin-like receptor 2DL4(KIR2DL4) is a Single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains.It belongs to the immunoglobulin superfamily. KIR2DL4 is expressed in all NK cells and some T cells. KIR2DL4 activates the cytotoxicity of NK cells, despite the presence of an immunoreceptor tyrosine-based inhibition motif (ITIM) in its cytoplasmic tail. The ITIM was not necessary for activation of lysis by KIR2DL4. The activation signal of KIR2DL4 was sensitive to inhibition by another ITIM-containing receptor. The activation-deficient mutant of KIR2DL4 inhibited the signal delivered by the activating receptor CD16.