insulin b chain

InsB (9-23) is an insulin B-chain peptide that binds to a class II histocompatibility complex (MHC) allele called I-Ag7.

Insulin β Chain Peptide (15-23), also referred to as INS, is an insulin-derived peptide that is specifically recognized by islet-associated T cells. The tetramer of Insulin β Chain Peptide (15-23) effectively stained the INS-reactive CTL clone G9C8; however, neither this tetramer nor the negative control tetramer (TUM) exhibited staining on the splenic CD8+ T cells obtained from NOD or 8.3-TCRαβ transgenic NOD mice.

ELOVL6-IN-5（compound B）是针对ELOVL6的抑制剂，后者为长链脂肪酸家族6的延长酶，负责饱和及单不饱和长链脂肪酸的延长，并且是糖尿病治疗中的有效靶点。此化合物能在饮食诱导肥胖（DIO）的小鼠模型中有效降低肝脏脂肪酸水平，尽管如此，通过ELOVL6-IN-5引起的ELOVL6抑制并未改善胰岛素抵抗问题。

Human proinsulin, the single-chain peptide precursor of insulin, consists of the insulin A and B chains connected by the 31 amino acid C-peptide. Cleavage of proinsulin by proteolytic enzymes produces insulin and free C-peptide.