human cathepsin k

ONO-5334 是一种具有选择性、口服活性和高效性的组织蛋白酶 K 抑制剂，具有抗 SAR-COV-2 和抗骨吸收活性，可用于研究骨质疏松症。

Relacatib (SB-462795) is a novel, potent, and orally active inhibitor of human cathepsins K, L, and V. It exhibits high affinity for these enzymes, with Ki values of 41 pM, 68 pM, and 53 pM, respectively. Moreover, Relacatib effectively inhibits endogenous cathepsin K in situ in human osteoclasts, as well as human osteoclast-mediated bone resorption, with IC 50 values of 45 nM and 70 nM, respectively. Additionally, in vitro studies demonstrate Relacatib's inhibitory effect on bone resorption in human tissue, while in vivo studies on cynomolgus monkeys further validate its efficacy in reducing bone resorption.

Odanacatib 是组织蛋白酶K（人 兔）的选择性抑制剂，IC50分别为0.2 nM 和 1 nM。