5-Monobutyl methotrexate is an antineoplastic antimetabolite with immunosuppressant properties. It is a TETRAHYDROFOLATE DEHYDROGENASE inhibitor and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component
Dichloromethotrexate is an enzyme dihydrofolate reductase inhibitor, thus preventing the synthesis of purine nucleotides and thymidylates and inhibiting DNA and RNA synthesis. This agent is metabolized and excreted by the liver.
Methotrexate monohydrate is a DHhF reductase inhibitor. Methotrexate monohydrate increases T cell apoptosis, decreases T cell activation and suppresses cytokine production.
3'-Chloromethotrexate is a chemotherapy agent and immune system suppressant. It can be used to treat cancer, autoimmune diseases, ectopic pregnancy, and medical abortions.