Anti-Phospho-TRIM28 (Ser824) Antibody (6F351) is a Rabbit antibody targeting Phospho-TRIM28 (Ser824). Anti-Phospho-TRIM28 (Ser824) Antibody (6F351) can be used in WB,IP.

IgG

6F351

Human

WB: 1:1000-2000; IP: 1:20-50

Monoclonal

A synthesized peptide: human TIF1 beta around the phosphorylation site of S824

Human

TRIM28

Transcription intermediary factor 1-beta

Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger.