hdac in 26

HDAC-IN-26 is a highly selective class I HDAC inhibitor with an EC 50 value of 4.7 nM.

HDAC6-IN-26（化合物23）对HDAC6具有制剂作用。

HDAC-IN-84 (compound 4a) 是一种有效的HDAC抑制剂，其IC50值对于HDAC1、HDAC2、HDAC3、HDAC6、HDAC8和HDAC11分别为0.0045, 0.015, 0.013, 0.038, 5.8和26 μM。HDAC-IN-84 能显著抑制白血病细胞的增殖且无毒性作用。

FLT3 VEGFR2-IN-1 (Compound 26) 是一种高效的FLT3 VEGFR2 HDAC抑制剂，其IC50分别为FLT3：14.5 nM，VEGFR2：3.9 nM，HDAC1：30.8 nM。它有效抑制STAT3和ERK1 2的磷酸化和白血病细胞的增殖，具备抗肿瘤活性，适用于急性髓系白血病研究。

HDAC HSP90-IN-4 能够明显抑制 HDAC 和 HSP90 的活性，化合物20（HDACIC50= 194 nM; HSP90αIC50= 153 nM）和化合物26（(HDACIC50= 360 nM; HSP90αIC50= 77 nM) 具有较强的 HDAC 和 HSP90α抑制效果。这两种化合物都能诱导 HSP90表达并下调 HSP90客户蛋白，而 HSP90客户蛋白在调节癌细胞的生存和侵袭中发挥着重要作用。

RO314724 is a HDAC inhibitor. RO314724 is also a a reversible, tightly binding, MMP inhibitor with a Ki of 26 nm. Matrix metalloproteinases (MMPs) belong to the key enzymes of the proteolytic destruction of cartilage matrix during chronic rheumatic diseases. Ro314724 displayed MMP-proteoglycanase inhibitory activity both in vitro and ex vivo and proved to be not harmful to the morphology, viability and proteoglycan biosynthesis of bovine articular cartilage explants.