etoposide phosphate

Etoposide phosphate is a phosphate salt of Etoposide, which binds to the enzyme topoisomerase II, then induces double-strand DNA breaks and inhibits DNA repair, leading to decreased DNA synthesis and tumor cell proliferation.

Etoposide phosphate disodium (BMY-40481 disodium), a phosphate ester prodrug of etoposide, functions as a potent chemotherapeutic agent by selectively inhibiting topoisomerase II, hindering the re-ligation of DNA strands. It is regarded as the active equivalent of etoposide, effectively inducing cell cycle arrest, apoptosis, and autophagy in cancer cells.

Heptelidic acid (Koningic acid) 是一种源自益生菌米曲霉的倍半萜内酯倍半萜类抗生素，是一种选择性 GAPDH 抑制剂，通过下调 caspase 从而抑制 Etoposide 诱导的细胞凋亡。Heptelidic acid 以浓度依赖性方式抑制 tau 纤维化，通过控制甘油醛-3-磷酸脱氢酶活性对肠外黑色素瘤发挥抗肿瘤作用。

10:0 PA (1,2-Didecanoyl-sn-glycero-3-phosphate) sodium 是一种阴离子脂质，适用于制备纳米乳剂，从而提升Etoposide的口服生物利用度。