dr-3

(R)-Ofloxacin is a R-isomer of Ofloxacin, an antibiotic used to treat a number of bacterial infections.

TDR32570 is an antimalarial agent.

BMS-986020 (AM152) 是一种高亲和力溶血磷脂酸受体 1 拮抗剂，有用于特发性肺纤维化的研究潜力。它抑制胆汁酸和磷脂转运蛋白，抑制 BSEP、MRP4 和 MDR3，IC50值分别为 4.8、6.2 和 7.5 μM。

BMS-986020 sodium (AM152 sodium) 是一种高亲和力的LPA1(Lysophosphatidic Acid Receptor 1)拮抗剂,可用于研究特发性肺纤维化，能够减慢用力肺活量(FVC)和肺功能下降速度。BMS-986020能够抑制胆汁酸和磷脂转运蛋白(BSEP,MRP4,MDR3)，改变胆汁稳态。

Indirubin-3′-oxime 是一种有效的细胞周期蛋白依赖性蛋白激酶抑制剂，是 indirubin 的合成衍生物。它可通过激活软骨细胞中的 Wnt/β-catenin 信号来促进身高增长，可能在阿尔茨海默病的神经元凋亡中发挥作用。

BIO5192 hydrate is a selective and potent integrin α4β1 (VLA-4) inhibitor (Kd<10 pM). BIO5192 hydrate selectively binds to α4β1 (IC50=1.8 nM) over a range of other integrins. BIO5192 hydrate results in a 30-fold increase in mobilization of murine hematopoietic stem and progenitors (HSPCs) over basal levels[1][2]. The combination of BIO5192 hydrate (1 mg/kg; i.v.) and Plerixafor (5 mg/kg; s.c.) exert an additive effect on progenitor mobilization[1].BIO5192 hydrate (30 mg/kg; s.c; bid; during days 5 through 14) delays paralysis associated with EAE (experimental autoimmune encephalomyelitis)[2].BIO5192 hydrate (1 mg/kg, i.v.) shows the terminal half-life is 1.1 hours. BIO5192 hydrate (3, 10, and 30 mg/kg; s.c.) shows half-lives of 1.7, 2.7, and 4.7 hours, respectively. The blood plasma curves show that the AUC for the s.c. route of administration increased about 2.5-fold from 5,460 h*ng/ml for the 3 mg/kg dose to 14,175 h*ng/ml for the 30 mg/kg[1]. Animal Model: C57BL/6J x 129Sv/J F1 mice[1] [1]. Ramirez P, et al. BIO5192, a small molecule inhibitor of VLA-4, mobilizes hematopoietic stem and progenitor cells. Blood. 2009;114(7):1340‐1343. [2]. Leone DR, et al. An assessment of the mechanistic differences between two integrin alpha 4 beta 1 inhibitors, the monoclonal antibody TA-2 and the small molecule BIO5192, in rat experimental autoimmune encephalomyelitis. J Pharmacol Exp Ther. 2003;305(3):1150-1162.

ODN D-SL03是C类CpG寡核苷酸，能诱导PBMCs产生高水平IFN-α，激活人B细胞、NK细胞和单个核细胞，同时上调PBMCs亚群表面CD80、CD86和HLA-DR的表达，还能抑制肿瘤生长。ODN D-SL03序列：5'-tcgcgaacgttcgccgcgttcgaacgcgg-3'。

LAG-3cyclic peptide inhibitor C25 是一种LAG-3抑制剂，与人LAG-3蛋白具有较高亲和力，Kd 值为 0.66 μM。它可以阻断LAG-3与HLA-DR(MHC-II)的相互作用，从而激活 CD8+T 细胞。LAG-3cyclic peptide inhibitor C25 适用于肿瘤研究。