dj 1

DJ-1-IN-1 (compound 797780-71-3) 作为一种有效的DJ-1抑制剂，在ACHN细胞中展示出了明显的抗增殖特性，其IC50达到了12.18 μM。此外，该化合物还能够抑制Wnt信号通路，因而在癌症研究领域具有应用潜力。

Protein deglycase DJ-1 against-1（compound 23）能够穿透血脑屏障（BBB）并结合DJ-1蛋白的C106区域，防止DJ-1过度氧化,增强细胞对氧化应激的抵抗力，从而恢复神经毒素MPTP诱导的帕金森病（PD）模型中观察到的神经元细胞死亡和运动缺陷。

DJ101is an effective and metabolically stable inhibitor of tubulin. It can circumvent the drug efflux pumps responsible for multidrug resistance of existing tubulin inhibitors.

NDJ18 is a potent and selective SIRT2 inhibitor which validated the in silico protocol and opened up the possibility for generalization and broadening of its application. The anticancer effects of the most potent compound NDJ18 were examined on the triple-negative breast cancer cell line. Results indicated that NDJ18 represents a promising structure suitable for further evaluation.

GSK717 是 NOD2(核苷酸结合寡聚结构域 2) 的选择性抑制剂。它抑制壁酰二肽 (MDP) 诱导的 NOD2 介导的信号转导，抑制 MDP 刺激的 HEK293 hNOD2 细胞分泌 IL-8 (IC50为 400 nM)。

CRT0063465是一种同时针对人类PGK1和Stress Sensor DJ1的配体，其对PGK1的Kd值为24 μM。该化合物能够调节端粒蛋白复合体的形成及端粒长度。