diuresis

VU0134992 hydrochloride 是一个亚型偏好的，具有口服活性和选择性的内向整流钾通道Kir4.1阻滞剂，IC50为 0.97 μM。在 -120 mV 时，VU0134992 hydrochloride 对同分 Kir4.1 比 Kir4.1/5.1 共分通道 (IC50=9 μM) 高出 9 倍的选择性。

VU 0134992 是一个亚型偏好的，口服有效的和选择性的内向整流钾通道 Kir4.1阻滞剂，IC50为 0.97 μM。在 -120 mV 时，VU0134992对同分 Kir4.1 比 Kir4.1/5.1 共分通道 (IC50=9 μM) 高出 9 倍的选择性。

Theophylline monohydrate (Quibron) 似乎抑制磷酸二酯酶和前列腺素的产生，调节钙通量和细胞内钙分布，并拮抗腺苷。茶碱是黄嘌呤的天然生物碱衍生物，从植物山茶花和小粒咖啡中分离出来。在生理上，该药剂可放松支气管平滑肌，产生血管舒张（脑血管除外），刺激中枢神经系统，刺激心肌，利尿，增加胃酸分泌；它还可以抑制炎症并改善横膈膜的收缩性。

Hydrochlorothiazide (HCTZ) 是一种口服有效的噻嗪类的利尿药，可抑制转化 TGF-β/Smad 信号通路。它通过打开钙激活钾 (KCA) 通道发挥直接的血管松弛作用。它改善心脏功能，减少纤维化并具有降压作用。

Perindopril erbumine (S9490-3) 是一种长效血管紧张素转换酶抑制剂。

Chlorazanil 是一种三嗪类衍生化合物，属于新型、可口服且低毒性的利尿剂。其药理作用机制为选择性阻断肾远曲小管中钠离子与氯离子的重吸收，从而促进利尿作用并调节电解质平衡，而不会引起显著的系统性毒性。此外，Chlorazanil 通过促进前列腺素合成来增强肾脏前列腺素活性。基于此特性，Chlorazanil 在肾脏生理学研究及利尿剂药物开发中具有重要价值。

Demeclocycline (Declostatin) 是一种四环素类抗生素，产自金霉素链霉菌（Streptomyces aureofaciens）菌株。Demeclocycline 具有抗菌活性，能抑制血管加压素对肾小管的作用，从而导致利尿。Demeclocycline 可用诱导尿崩症和急性肾衰竭。

8-Aminoguanine 是一种内源性嘌呤，能够抑制PNPase (嘌呤核苷磷酸化酶)，并可诱发利尿/排钠/糖尿。

PD 117302 is a nonpeptide opioid compound. It is a selective kappa-opioid agonist. PD 117302 causes naloxone-reversible locomotor impairment and diuresis. It is an Anti-Arrhythmia Agent, an Anticonvulsants, a Cardiovascular Agent, and a Central Nervous Sy

Acefylline piperazine is a stimulant drug of the xanthine chemical class. It acts as an adenosine receptor antagonist. Acephylline piperazine is a theophylline derivative with a direct bronchodilator action. It has the advantages over theophylline in being far less toxic and producing minimal gastric irritation. It is indicated for the treatment of asthma, emphysema, acute and chronic bronchitis associated with bronchospasm.Acefylline relaxes smooth muscles, relieves bronchospasm & has a stimulant effect on respiration. It stimulates the myocardium & central nervous system, decreases peripheral resistance & venous pressure & causes diuresis. The mechanism of action is still not clear, inhibition of phosphodiesterase with a resulting increase in intracellular cyclic AMP does occur, but not apparently at concentrations normally used for clinical effect. Other proposed mechanisms of action include adenosine receptor antagonism, prostaglandin antagonism & effects on intracellular......

Demeclocycline calcium is a semisynthetic tetracycline antibiotic which was derived from a strain of Streptomyces aureofaciens. Demeclocycline binds to bacterial 30S ribosomal subunit and prevents binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis. Demeclocycline also inhibits the effect of vasopressin on the renal tubules, thereby causing diuresis.

8-Aminoinosine is an endogenous 8-aminopurine that induces diuresis, natriuresis, and glucosuria by inhibiting purine nucleoside phosphorylase (PNPase).