d20:1

Sphingosines are long-chain base precursors of cellular sphingolipids used directly in the synthesis of ceramide, which in combination with sialic acid forms ganglioside. Sphingosine can exist in four stereoisomers, however only sphingosine occurs naturally. Compared to other sphingolipids throughout the body, which are predominantly composed of C-18 sphingosine, only central nervous system (CNS) gangliosides contain significant amounts of sphingosine. The concentration of sphingosine within mammalian brain gangliosides apparently increases with developmental maturation. Furthermore, the ratio of C-18 to C-20 sphingosine in the brain is thought to be related to some nervous system degeneration processes.

Vistusertib (AZD2014) 是一种ATP 竞争性的mTOR 抑制剂，IC50为 2.81 nM。它抑制mTORC1和mTORC2复合物。

CID 2011756 是一种具有抗肿瘤活性的ATP 竞争性广谱PKD 抑制剂，对 PKD1 的IC50值为 3.2 µM，在细胞中对 PKD2 和 PKD3 的IC50值分别为 0.6 和 0.7 µM。

CACPD2011a-0001278239 是一种β2AR混合激动剂，显示出对野生型和T164I β2AR变体的广泛高亲和力结合，并且没有细胞毒性和致突变性，适用于哮喘研究。

HA-22 is a Ca(2+)-channel blocker.

CD2019 is a retinoic acid receptor beta (rarbeta) agonist, overcoming inhibition of axonal outgrowth via phosphoinositide 3-kinase signalling in the injured adult spinal cord.

Sphinganine (d20:0) is a natural isomer of dihydro-D-erythro-sphinganine (sphinganine (d18:0); that is a precursor of ceramide and sphingosine as well as a substrate for sphingosine kinases, which generate sphingosine-1-phosphate (d18:1) . In S. cerevisiae, the amount of sphinganine (d20:0) increases 10.8-fold in response to heat stress, indicating it is involved in heat stress adaptation. Sphinganine levels increase significantly in response to certain mycotoxins, including fumonisins as well as in some cancers. Sphinganine can block protein kinase C activation in some cases but not others.