d14:1

Sphingosine (d14:1) is a bioactive sphingolipid that has been found in B. mori (silkworm), P. clarkii (crayfish), and A. aurita (jellyfish) extracts. It increases the germination rate of N. rileyi, an entomopathogenic fungus, with an EC50 value of 10.2 nM. Sphingosine (d14:1) inhibits protein kinase C (PKC) in vitro (IC50 = 7.3 mol%) as well as superoxide generation induced by phorbol 12-myristate 13-acetate in neutrophils and reduces growth of CHO cells (IC50s = 19 and 8 μM, respectively).

C2 Ceramide (d14:1/2:0) is a bioactive sphingolipid. Dietary administration of C2 ceramide (d14:1/2:0) (100 μM) induces lipotoxic cardiomyopathy via increasing diastolic and systolic diameter as well as reducing fractional shortening and the number of normal cardiac contractile events in Drosophila.

Azido sphingosine (d14:1) 是一种能够参与点击化学反应的可点击鞘脂。

NBD-14189 是一种有效的 HIV-1 进入拮抗剂，能够作用于 HIV-1HXB2 假病毒 (IC50: 89 nM)。NBD-14189 能够结合 HIV-1 gp120，并具有显著的抗病毒作用 (EC50<200 nM)。

2-METHYL-4-PHENYL-THIAZOLE是一个片段分子，CAS号为1826-16-0，可作为分子拼接、扩展和修饰的重要骨架，为新型候选药物的设计与筛选提供结构基础与研究工具，常用于药物发现、药物合成等相关研究。

LYP-IN-4（compound D14）是一种针对淋巴酪氨酸磷酸酶（LYP）的可逆且特异性抑制剂，具有Ki值1.34 μM和IC50值3.52 μM。该化合物通过抑制LYP来调控TCR信号传递，并上调PD-1/PD-L1的表达，以此增强抗肿瘤免疫反应。此外，LYP-IN-4能够激活T细胞、抑制M2型巨噬细胞的极化，并在MC38同基因小鼠模型中抑制肿瘤生长。

Probenecid-d14 是 Probenecid 的氘代物。Probenecid 是一种有效的 TRPV2（瞬时受体电位香草酸受体通道 2）选择性激动剂，同时也是 pannexin 1 通道的抑制剂。