d14:1

Sphingosine (d14:1) is a bioactive sphingolipid that has been found in B. mori (silkworm), P. clarkii (crayfish), and A. aurita (jellyfish) extracts. It increases the germination rate of N. rileyi, an entomopathogenic fungus, with an EC50 value of 10.2 nM. Sphingosine (d14:1) inhibits protein kinase C (PKC) in vitro (IC50 = 7.3 mol%) as well as superoxide generation induced by phorbol 12-myristate 13-acetate in neutrophils and reduces growth of CHO cells (IC50s = 19 and 8 μM, respectively).

C2 Ceramide (d14:1 2:0) is a bioactive sphingolipid. Dietary administration of C2 ceramide (d14:1 2:0) (100 μM) induces lipotoxic cardiomyopathy via increasing diastolic and systolic diameter as well as reducing fractional shortening and the number of normal cardiac contractile events in Drosophila.

NBD-14189 是一种有效的 HIV-1 进入拮抗剂，能够作用于 HIV-1HXB2 假病毒 (IC50: 89 nM)。NBD-14189 能够结合 HIV-1 gp120，并具有显著的抗病毒作用 (EC50<200 nM)。

LYP-IN-4（compound D14）是一种针对淋巴酪氨酸磷酸酶（LYP）的可逆且特异性抑制剂，具有Ki值1.34 μM和IC50值3.52 μM。该化合物通过抑制LYP来调控TCR信号传递，并上调PD-1 PD-L1的表达，以此增强抗肿瘤免疫反应。此外，LYP-IN-4能够激活T细胞、抑制M2型巨噬细胞的极化，并在MC38同基因小鼠模型中抑制肿瘤生长。