balb/c nude mice

Oxiconazole nitrate (Ro 13-8996) 是广谱抗真菌药物，抑制T. tonsurans 和T.rubrum 的生长，MIC90值分别为 0.25 和 0.5 μg mL。

WRN inhibitor 14 (compound S35) 是一种口服WRN抑制剂，具有抗癌活性，可抑制 BALB c 裸鼠 SW48 异种移植模型中的肿瘤生长。

SGK1-IN-6 (compound 12f) 是一种具有 IC50 值为 0.39 μM 的 SGK1 抑制剂。在 BALB c 裸鼠的 PC3 异种移植模型中，SGK1-IN-6 有效抑制肿瘤生长，并且未产生任何可观察的毒性。

Tubulin polymerization-IN-6 (compound 5f) is a potent inhibitor of tubulin polymerization, with an IC50 of 1.09 μM. It not only inhibits cell migration and tube formation but also has anti-angiogenic properties. Additionally, Tubulin polymerization-IN-6 has been found to effectively hinder tumor growth in HT29 xenograft Balb c nude mice [1].

Xylocydine is a novel Cdk inhibitor, which is an effective inducer of apoptosis in hepatocellular carcinoma cells in vitro and in vivo. Xylocydine also strongly inhibits the activity of Cdk7 and Cdk9, in vitro as well as in cell cultures, that is temporally associated with apoptotic cell death in xylocydine-induced HCC cells. Xylocydine can effectively suppress the growth of HCC xenografts in Balb C-nude mice by preferentially inducing apoptosis in the xenografts, whereas the drug did not cause any apparent toxic effect on other tissues.Xylocydine is a good candidate for an anti-cancer drug for HCC therapy.