app-3

ANAPP3 is a P2x-purinoceptor antagonist. It affects contractions in various muscle groups and tissues.

XIIa-IN-1-IN-3（Compound 22）作为一种Factor XIIa抑制剂，其Kiapp值为97.8 nM。该化合物主要应用于血栓形成的研究。

GDC0084 (RG7666) 是一种具有潜在抗肿瘤活性的 PI3K 抑制剂。 GDC0084 (RG7666) 特异性抑制 PI3K AKT 激酶（或蛋白激酶 B）信号通路中的 PI3K，从而抑制 PI3K 信号通路的激活。这可能导致易感肿瘤细胞群中的细胞生长和存活受到抑制。

1,7-Diphenyl-4-hepten-3-one 可从 Alpinia officinarum 中分离得到的化合物，通过激活 Nrf2 通路抑制细胞焦亡，可减轻 APP PS1 小鼠的认知障碍并减轻了病理损伤，阻止氧化应激损伤并降低焦亡相关蛋白的水平。1,7-Diphenyl-4-hepten-3-one 可改善 Aβ 诱导的 HT22 细胞的增殖，可用于研究阿尔茨海默病。

APP-CHMINACA is a synthetic cannabinoid (CB) featuring a 1-(cyclohexylmethyl)-1H-indazole-3-carboxamide (CHMINACA) base. It displays a 10-fold greater affinity for the central CB1 receptor than that of JWH 018.

16F16 is a protein disulfide isomerase (PDI) inhibitor.1It inhibits PDI reductase activity in an enzyme assay when used at concentrations ranging from 1 to 100 μg/ml.116F16 reduces PC12 cell apoptosis induced by the misfolded huntingtin protein HTTQ103. It suppresses PDI-dependent mitochondrial outer membrane permeabilization (MOMP) in isolated PC12 cell mitochondria. 16F16 (2, 3, 4, and 10 μM) reduces HTTN90Q73mutant huntingtin-induced medium spinal neuron death and MOMP in rat corticostriatal slices. It also reduces pyramidal neuron death induced by amyloid-β precursor protein (APP) in rat corticostriatal slices. 1.Hoffstrom, B.G., Kaplan, A., Letso, R., et al.Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteinsNat. Chem. Biol.6(12)900-906(2010)

7-Deoxy-trans-dihydronarciclasine 作为生物碱，担任烟草花叶病毒（TMV）抑制剂（IC50: 1.80 μM），亦具有抗神经炎症作用，能够降低Tg2576小鼠大脑皮质中Aβ与APP水平。

APP-FUBINACA 是苯丙氨酸酰胺基吲唑-3-羧酰胺的衍生物，属于大麻素受体激动剂，具有神经刺激作用。

Rasagiline-13C3is intended for use as an internal standard for the quantification of rasagiline by GC- or LC-MS. Rasagiline is an inhibitor of monoamine oxidase B (MAO-B; IC50= 4.43 nM for the rat brain enzyme).1It is selective for MAO-B over MAO-A (IC50= 412 nM for the rat brain enzyme). It inhibits serum and NGF withdrawal-induced apoptosis of PC12 cells when used at concentrations ranging from 0.01 to 100 μM.2Rasagiline inhibits rat brain MAO-Bin vivo(ED50= 0.1 mg kg).1It reduces cerebral edema in a mouse model of traumatic brain injury.2Rasagiline (0.1 mg kg) reduces cortical and hippocampal levels of full-length and soluble amyloid precursor protein (APP) in rats and mice. It also reduces α-synuclein-induced substantia nigral neuron loss and improves motor dysfunction in a mouse model of Parkinson's disease.3Formulations containing rasagiline have been used in the treatment of Parkinson's disease. 1.Youdim, M.B.H., Gross, A., and Finberg, J.P.Rasagiline [N-propargyl-1R(+)-aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase BBrit. J. Pharmacol.132(2)500-506(2001) 2.Youdim, M.B.H., and Weinstock, M.Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R) aminoindan-5-YL)-ethyl methyl carbamate]Cell. Mol. Neurobiol.21(6)555-573(2001) 3.Kang, S.S., Ahn, E.H., Zhang, Z., et al.α-Synuclein stimulation of monoamine oxidase-B and legumain protease mediates the pathology of Parkinson's diseaseEMBO J.37(12)e98878(2018)

Licoflavonol 是一种可从甘草中提取的黄酮类化合物，是鼠伤寒沙门氏菌血清型 3 型分泌系统抑制剂，通过抑制 β 位点 APP 裂解酶 1 （BACE1） 转录来抑制 Abeta 分泌。