antibiotic development

ADEP-14（亦称Acyldepsipeptide-14）为一种Acyldepsipeptide类抗生素，通过结合ClpP蛋白质活性，在细胞内促进新合成蛋白和Ftsz蛋白的降解。该过程可能引发细胞死亡，使其成为化合物开发中有潜力的技术。

Laterocidine是一种大环脂肽类抗生素，以其对革兰氏阴性细菌的显著抗菌性能而闻名，尤其是对Pseudomonas aeruginosa和colistin耐药性E. coli的有效性。该化合物也因其低抗生素耐药性发展风险而受到关注。

Viquidacin ( NXL-101) is an oral intravenous antibiotic that targets Gram-positive bacteria such as MRSA. In 2008, Novexel announced it had discontinued the development of Viquidacin (NXL 101).

Deethylindanomycin is a polyether antibiotic that has been found in S. setonii. It is active against a variety of Gram-positive bacteria, including various strains of S. aureus and Streptococcus, as well as one strain of S. pneumoniae (MICs = 4, 4, and 2 μg ml, respectively). It is also active against coccidia in vitro, inhibiting E. tenella development, but is inactive against E. tenella infection in chicks when administered at a dose of 200 μg g in the diet. Deethylindanomycin acts as an ionophore in lipid bilayer membranes and is more selective for potassium ions than calcium, magnesium, and sodium ions. It induces histamine release from rodent mast cells and human basophils in vitro in a calcium-dependent manner.

BING 是一种从日本青鳉鱼中分离的抗菌肽。该肽对多种病原菌，包括耐药菌株，具有广谱毒杀作用。BING 可导致革兰氏阴性菌的周质肽基脯氨酰异构酶功能失调，并降低在抗生素耐药性产生中至关重要的cpxR的 RNA 水平。

Anoplin 是由独居胡蜂 (Anoplius samariensis) 毒液中提取的一种抗微生物肽。该化合物对多种包括革兰氏阳性和阴性细菌的抗菌活性表现出效力。此外，Anoplin 亦有望用于开发新型抗生素。

Cyclic L27-11 是一款环状肽类模拟抗生素，主要针对诸如假单胞菌属 (Pseudomonas sp.) 等特定细菌展示出高效的抗菌特性。特别是对铜绿假单胞菌 (P. aeruginosa) 显示了纳摩尔级别的高效抗菌活性。该化合物通过破坏细菌外膜蛋白 LptD 功能，干预脂多糖 (LPS) 的转运机制，从而引发细菌细胞内膜样物质的积累，影响细胞生存，这种机制为Cyclic L27-11 在抗菌剂开发中提供了应用潜力。