Duocarmycin

Duocarmycin is a DNA minor groove binding alkylating agent and explored as drug–antibody conjugates (ADCs) . Duocarmycin is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity.

Duocarmycin TM 是一种有抗肿瘤活性的抗生素，也是一种 DNA 烷化剂。

Duocarmycin analog-2 是有效的 DNA 烷基化剂，表现出抗肿瘤作用，能够用于免疫偶联物的合成。

Mal-PEG4-VC-PAB-DMEA-duocarmycin SA 是一种硫醇反应型 Drug-linker,duocarmycin SA 是一种非常有效的、具有口服活性的细胞毒性剂，可用于抗体-药物偶联物（ADC）的合成。

Duocarmycin A, an antitumor antibiotic, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results in HLC-2 cells typically apoptotic changes.

Seco-Duocarmycin TM is an agent of DNA alkylator belonging to Duocarmycins family that inhibits DNA synthesis. It used as the cytotoxic component in antibody-drug conjugates (ADC).

Duocarmycin Analog is used as an DNA alkylator and ADC cytotoxin. Duocarmycin Analog is an analog of Duocarmycin.

Mal-PEG4-VC-PAB-DMEA-Seco-Duocarmycin SA is an antibody-drug conjugate linker that incorporates the antitumor antibiotic Duocarmycin SA, connected through the Mal-PEG4-VC-PAB-DMEA-Seco linker, for targeted cancer therapy.

Fmoc-Val-Cit-PAB-Duocarmycin TM is a drug-linker conjugate designed for antibody-drug conjugation (ADC), utilizing the antitumor antibiotic Duocarmycin TM. It is connected through the linker Fmoc-Val-Cit-PAB.

DBCO-PEG4-VC-PAB-DMEA-Duocarmycin SA 是一种是一种点击反应型 Drug-linker，含有 DBCO 基团，可以和含有 Azide 基团的分子发生环张力 (strain) 促进的炔-叠氮环加成反应 (SPAAC)。duocarmycin SA 是一种非常有效的、具有口服活性的细胞毒性剂，DBCO-PEG4-VC-PAB-DMEA-Duocarmycin SA可用于抗体-药物偶联物（ADC）的合成。

Seco-Duocarmycin SA is a highly potent DNA alkylator used as an ADC cytotoxin.

MA-PEG4-VC-PAB-DMEA-duocarmycin TM 是一种硫醇反应型 Drug-linker,Duocarmycin TM 是一种有效的有抗肿瘤活性的抗生素，常用于抗体-药物偶联物（ADC）的合成。

Duocarmycin SA is an extremely potent cytotoxic agent and antitumor antibiotic that induces sequence-selective alkylation of duplex DNA, with an IC50 of 10 pM. It demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells when combined with proton radiation in vitro.

Duocarmycin DM，一种DNA小沟烷基化剂（DNA minor-groove alkylator），作为抗体活性分子结合物（ADCs）的毒素，因其独特结构显示出抗癌活性。

Mal-PEG4-VC-PAB-DMEA-duocarmycin-DM 是一种硫醇反应型 Drug-linker,Duocarmycin DM 是一种 DNA 小沟烷基化剂，可作为 ADC 结合物毒素，用于抗体-药物偶联物（ADC）的合成。

G3-VC-PAB-DMEA-Duocarmycin DM (Compound LD-1) 为一种以duocarmycin为基础的连接分子，主要应用于ADC制备。

MA-PEG4-vc-PAB-DMEA-duocarmycin DM 是一种ADC药物连接物缀合物，由抗癌抗生素Duocarmycin DM 和 MA-PEG4-vc-PAB-DMEA连接而成。

Duocarmycin MB can be used against multi-drug resistant cell lines. Duocarmycin MB is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove.

Duocarmycin A (GMP)是 Duocarmycin A 的 GMP 级别试剂。Duocarmycin A 是一种抗肿瘤抗生素，属于 DNA 甲基化剂，能够有效地在 DNA 中富含腺嘌呤序列的 3' 端将腺嘌呤 N3 甲基化。作为一种化疗药物，杜卡霉素 A 会导致 HLC-2 细胞出现典型的凋亡变化。

Duocarmycin GA, an antibody drug conjugate (ADC) toxin and a DNA alkylating agent, effectively targets and binds in the minor groove of DNA. It is particularly potent against multi-drug resistant cell lines, offering a strategic approach in combating resistance.

MC-Val-Cit-PAB-duocarmycin is an antibody-drug conjugate (ADC) linker that combines duocarmycin, a potent DNA minor groove-binding alkylating agent, with an antitumor drug through the MC-Val-Cit-PAB linker, exhibiting significant antitumor activity.

(S)-Seco-Duocarmycin SA 是一种 DNA 烷化剂，也是具有高效抗肿瘤活性的抗生素，可用于合成 ADC 化合物。

Duocarmycin MA can be used against multi-drug resistant cell lines.Duocarmycin MA is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove.

Seco-DUBA, a duocarmycin (DUBA) prodrug, possess two hydroxyl groups suitable for antibody coupling through a linker. This compound, serving as a precursor, enables the synthesis of antibody-drug conjugates (ADCs).