Duocarmycin

Duocarmycin is a DNA minor groove binding alkylating agent and explored as drug–antibody conjugates (ADCs) . Duocarmycin is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity.

Duocarmycin SA is an extremely potent cytotoxic agent and antitumor antibiotic that induces sequence-selective alkylation of duplex DNA, with an IC50 of 10 pM. It demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells when combined with proton radiation in vitro.

Duocarmycin TM 是一种有抗肿瘤活性的抗生素，也是一种 DNA 烷化剂。

Seco-Duocarmycin SA is a highly potent DNA alkylator used as an ADC cytotoxin.

Seco-Duocarmycin TM is an agent of DNA alkylator belonging to Duocarmycins family that inhibits DNA synthesis. It used as the cytotoxic component in antibody-drug conjugates (ADC).

Duocarmycin A, an antitumor antibiotic, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results in HLC-2 cells typically apoptotic changes.

Fmoc-Val-Cit-PAB-Duocarmycin TM is a drug-linker conjugate designed for antibody-drug conjugation (ADC), utilizing the antitumor antibiotic Duocarmycin TM. It is connected through the linker Fmoc-Val-Cit-PAB.

Mal-PEG4-VC-PAB-DMEA-Seco-Duocarmycin SA is an antibody-drug conjugate linker that incorporates the antitumor antibiotic Duocarmycin SA, connected through the Mal-PEG4-VC-PAB-DMEA-Seco linker, for targeted cancer therapy.

Duocarmycin Analog is used as an DNA alkylator and ADC cytotoxin. Duocarmycin Analog is an analog of Duocarmycin.

Mal-PEG4-VC-PAB-DMEA-duocarmycin SA 是一种硫醇反应型 Drug-linker,duocarmycin SA 是一种非常有效的、具有口服活性的细胞毒性剂，可用于抗体-药物偶联物（ADC）的合成。

MA-PEG4-VC-PAB-DMEA-duocarmycin TM 是一种硫醇反应型 Drug-linker,Duocarmycin TM 是一种有效的有抗肿瘤活性的抗生素，常用于抗体-药物偶联物（ADC）的合成。

Mal-PEG4-VC-PAB-DMEA-duocarmycin-DM 是一种硫醇反应型 Drug-linker,Duocarmycin DM 是一种 DNA 小沟烷基化剂，可作为 ADC 结合物毒素，用于抗体-药物偶联物（ADC）的合成。

DBCO-PEG4-VC-PAB-DMEA-Duocarmycin SA 是一种是一种点击反应型 Drug-linker，含有 DBCO 基团，可以和含有 Azide 基团的分子发生环张力 (strain) 促进的炔-叠氮环加成反应 (SPAAC)。duocarmycin SA 是一种非常有效的、具有口服活性的细胞毒性剂，DBCO-PEG4-VC-PAB-DMEA-Duocarmycin SA可用于抗体-药物偶联物（ADC）的合成。

Duocarmycin analog-2 是有效的 DNA 烷基化剂，表现出抗肿瘤作用，能够用于免疫偶联物的合成。

Duocarmycin DM，一种DNA小沟烷基化剂（DNA minor-groove alkylator），作为抗体活性分子结合物（ADCs）的毒素，因其独特结构显示出抗癌活性。

MA-PEG4-vc-PAB-DMEA-duocarmycin DM 是一种ADC药物连接物缀合物，由抗癌抗生素Duocarmycin DM 和 MA-PEG4-vc-PAB-DMEA连接而成。

G3-VC-PAB-DMEA-Duocarmycin DM (Compound LD-1) 为一种以duocarmycin为基础的连接分子，主要应用于ADC制备。

Duocarmycin GA, an antibody drug conjugate (ADC) toxin and a DNA alkylating agent, effectively targets and binds in the minor groove of DNA. It is particularly potent against multi-drug resistant cell lines, offering a strategic approach in combating resistance.

Duocarmycin MA can be used against multi-drug resistant cell lines.Duocarmycin MA is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove.

Duocarmycin MB can be used against multi-drug resistant cell lines. Duocarmycin MB is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove.

(S)-Seco-Duocarmycin SA 是一种 DNA 烷化剂，也是具有高效抗肿瘤活性的抗生素，可用于合成 ADC 化合物。

Duocarmycin A (GMP)是 Duocarmycin A 的 GMP 级别试剂。Duocarmycin A 是一种抗肿瘤抗生素，属于 DNA 甲基化剂，能够有效地在 DNA 中富含腺嘌呤序列的 3' 端将腺嘌呤 N3 甲基化。作为一种化疗药物，杜卡霉素 A 会导致 HLC-2 细胞出现典型的凋亡变化。

MC-Val-Cit-PAB-duocarmycin is an antibody-drug conjugate (ADC) linker that combines duocarmycin, a potent DNA minor groove-binding alkylating agent, with an antitumor drug through the MC-Val-Cit-PAB linker, exhibiting significant antitumor activity.

Seco-DUBA, a duocarmycin (DUBA) prodrug, possess two hydroxyl groups suitable for antibody coupling through a linker. This compound, serving as a precursor, enables the synthesis of antibody-drug conjugates (ADCs).