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Targets Recommended: DNA Alkylation Antibiotic ADC Cytotoxin

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Cat. No. Product Name Target Signaling Pathways
T11120 Duocarmycin TM

DNA Alkylation; Antibiotic; ADC Cytotoxin Antibody-drug Conjugate/ADC Related; DNA Damage/DNA Repair; Microbiology/Virology
Duocarmycin TM 是一种有抗肿瘤活性的抗生素,也是一种 DNA 烷化剂。
T11119 Duocarmycin DM free base

Duocarmycin

Others; ADC Cytotoxin Antibody-drug Conjugate/ADC Related; Others
Duocarmycin is a DNA minor groove binding alkylating agent and explored as drug–antibody conjugates (ADCs) . Duocarmycin is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity.
T11118 Duocarmycin SA

Others; ADC Cytotoxin Antibody-drug Conjugate/ADC Related; Others
Duocarmycin SA is an extremely potent cytotoxic agent and antitumor antibiotic that induces sequence-selective alkylation of duplex DNA, with an IC50 of 10 pM. It demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells when combined with proton radiation in vitro.
T11117 Duocarmycin MB

Others; ADC Cytotoxin Antibody-drug Conjugate/ADC Related; Others
Duocarmycin MB can be used against multi-drug resistant cell lines. Duocarmycin MB is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove.
T15180 Duocarmycin A

Caspase; ADC Cytotoxin Antibody-drug Conjugate/ADC Related; Apoptosis; Proteases/Proteasome
Duocarmycin A, an antitumor antibiotic, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results in HLC-2 cells typically apoptotic changes.
T18324 MC-Val-Cit-PAB-duocarmycin chloride

MC-Val-Cit-PAB-duocarmycin

Others; Drug-Linker Conjugates for ADC Antibody-drug Conjugate/ADC Related; Others
MC-Val-Cit-PAB-duocarmycin is an antibody-drug conjugate (ADC) linker that combines duocarmycin, a potent DNA minor groove-binding alkylating agent, with an antitumor drug through the MC-Val-Cit-PAB linker, exhibiting significant antitumor activity.
T11116 Duocarmycin MA

Others; ADC Cytotoxin Antibody-drug Conjugate/ADC Related; Others
Duocarmycin MA can be used against multi-drug resistant cell lines.Duocarmycin MA is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove.
T19300 Duocarmycin Analog

DNA Alkylation; ADC Cytotoxin Antibody-drug Conjugate/ADC Related; DNA Damage/DNA Repair
Duocarmycin Analog is used as an DNA alkylator and ADC cytotoxin. Duocarmycin Analog is an analog of Duocarmycin.
T11115 Duocarmycin GA

Others; ADC Cytotoxin Antibody-drug Conjugate/ADC Related; Others
Duocarmycin GA, an antibody drug conjugate (ADC) toxin and a DNA alkylating agent, effectively targets and binds in the minor groove of DNA. It is particularly potent against multi-drug resistant cell lines, offering a strategic approach in combating resistance.
T12813L Seco-Duocarmycin SA

DNA Alkylation; ADC Cytotoxin Antibody-drug Conjugate/ADC Related; DNA Damage/DNA Repair
Seco-Duocarmycin SA is a highly potent DNA alkylator used as an ADC cytotoxin.
T12875 Seco-Duocarmycin TM

Others; ADC Cytotoxin Antibody-drug Conjugate/ADC Related; Others
Seco-Duocarmycin TM is an agent of DNA alkylator belonging to Duocarmycins family that inhibits DNA synthesis. It used as the cytotoxic component in antibody-drug conjugates (ADC).
T12813 (S)-Seco-Duocarmycin SA

Others; ADC Cytotoxin Antibody-drug Conjugate/ADC Related; Others
(S)-Seco-Duocarmycin SA is a DNA alkylator, acts as a ADC cytotoxin for antibody-drug conjugates.
T73948 Duocarmycin DM

Others; ADC Cytotoxin Antibody-drug Conjugate/ADC Related; Others
Duocarmycin DM,一种DNA小沟烷基化剂(DNA minor-groove alkylator),作为抗体活性分子结合物(ADCs)的毒素,因其独特结构显示出抗癌活性。
T17982 Fmoc-Val-Cit-PAB-Duocarmycin TM

Others; Drug-Linker Conjugates for ADC Antibody-drug Conjugate/ADC Related; Others
Fmoc-Val-Cit-PAB-Duocarmycin TM is a drug-linker conjugate designed for antibody-drug conjugation (ADC), utilizing the antitumor antibiotic Duocarmycin TM. It is connected through the linker Fmoc-Val-Cit-PAB.
T63523 Duocarmycin analog-2

Others Others
Duocarmycin analog-2 是有效的 DNA 烷基化剂,表现出抗肿瘤作用,能够用于免疫偶联物的合成。
T18293 Mal-PEG4-VC-PAB-DMEA-Seco-Duocarmycin SA

Others; Drug-Linker Conjugates for ADC Antibody-drug Conjugate/ADC Related; Others
Mal-PEG4-VC-PAB-DMEA-Seco-Duocarmycin SA is an antibody-drug conjugate linker that incorporates the antitumor antibiotic Duocarmycin SA, connected through the Mal-PEG4-VC-PAB-DMEA-Seco linker, for targeted cancer therapy.
T70462 Pibrozelesin

Others Others
Pibrozelesin is a water-soluble derivative of duocarmycin B2 that alkylates DNA by binding to adenine-thymine (A-T)-rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis.
T38611 Seco-DUBA

Others; ADC Cytotoxin Antibody-drug Conjugate/ADC Related; Others
Seco-DUBA, a duocarmycin (DUBA) prodrug, possess two hydroxyl groups suitable for antibody coupling through a linker. This compound, serving as a precursor, enables the synthesis of antibody-drug conjugates (ADCs).

化合物

Duocarmycin TM
Cat.No: T11120
Synonym:
Target: DNA Alkylation, Antibiotic, ADC Cytotoxin
Duocarmycin DM free base
Cat.No: T11119
Synonym: Duocarmycin
Target: Others, ADC Cytotoxin
Duocarmycin SA
Cat.No: T11118
Synonym:
Target: Others, ADC Cytotoxin
Duocarmycin MB
Cat.No: T11117
Synonym:
Target: Others, ADC Cytotoxin
Duocarmycin A
Cat.No: T15180
Synonym:
Target: Caspase, ADC Cytotoxin
MC-Val-Cit-PAB-duocarmycin chloride
Cat.No: T18324
Synonym: MC-Val-Cit-PAB-duocarmycin
Target: Others, Drug-Linker Conjugates for ADC
Duocarmycin MA
Cat.No: T11116
Synonym:
Target: Others, ADC Cytotoxin
Duocarmycin Analog
Cat.No: T19300
Synonym:
Target: DNA Alkylation, ADC Cytotoxin
Duocarmycin GA
Cat.No: T11115
Synonym:
Target: Others, ADC Cytotoxin
Seco-Duocarmycin SA
Cat.No: T12813L
Synonym:
Target: DNA Alkylation, ADC Cytotoxin
Seco-Duocarmycin TM
Cat.No: T12875
Synonym:
Target: Others, ADC Cytotoxin
(S)-Seco-Duocarmycin SA
Cat.No: T12813
Synonym:
Target: Others, ADC Cytotoxin
Duocarmycin DM
Cat.No: T73948
Synonym:
Target: Others, ADC Cytotoxin
Fmoc-Val-Cit-PAB-Duocarmycin TM
Cat.No: T17982
Synonym:
Target: Others, Drug-Linker Conjugates for ADC
Duocarmycin analog-2
Cat.No: T63523
Synonym:
Target: Others
Mal-PEG4-VC-PAB-DMEA-Seco-Duocarmycin SA
Cat.No: T18293
Synonym:
Target: Others, Drug-Linker Conjugates for ADC
Pibrozelesin
Cat.No: T70462
Synonym:
Target: Others
Seco-DUBA
Cat.No: T38611
Synonym:
Target: Others, ADC Cytotoxin
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