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Targets Recommended: Apoptosis Mitophagy Dynamin Autophagy

1

抑制剂 & 化合物

4

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T1907 Mdivi-1

Mitochondrial division inhibitor 1

Apoptosis; Mitophagy; Dynamin; Autophagy Apoptosis; Autophagy; Cytoskeletal Signaling
Mdivi-1 (Mitochondrial division inhibitor 1) 是一种线粒体分裂抑制剂,抑制 DRP1 和 Dynamin I (IC50=1-10 μM)。Mdivi-1 可以抑制线粒体自噬。

化合物

Mdivi-1
Cat.No: T1907
Synonym: Mitochondrial division inhibitor 1
Target: Apoptosis, Mitophagy, Dynamin, Autophagy
Cat. No. Product Name Species Expression System
TMPH-01254 DNM1 Protein, Human, Recombinant (His)

DNM,Dynamin,Dynamin-1,DNM1

Human E. coli
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.
TMPH-01255 DNM1L Protein, Human, Recombinant (His & Myc)

Dynamin-like protein IV,Dynamin-related protein 1,D...

Human E. coli
Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes. While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis...
TMPJ-01406 MOB4 Protein, Human, Recombinant (His)

PREI3,MOBKL3,Mps One Binder Kinase Activator-Like 3,Mob1...

Human E. coli
MOB-Like Protein Phocein is a member of the MOB1/Phocein Family. MOB-Like Protein Phocein is associated with membranes and the Golgi stacks. It is present in the cytosol, where it behaves as a protein complex. It has been shown that MOB-Like Protein Phocein interacts with DNM1, EPS15 and Nucleoside Diphosphate Kinase. MOB-Like Protein Phocein is the major partner of Striatin Family members and may play a important role in membrane trafficking, specifically in membrane budding reactions.
TMPJ-01307 PACSIN1 Protein, Human, Recombinant (His)

Protein Kinase C and Casein Kinase Substrate in Neurons Prot...

Human Human Cells
Protein Kinase C and Casein Kinase Substrate in Neurons Protein 1 (PACSIN1) belongs to the PACSIN family. PACSIN1 contains one FCH domain and one SH3 domain. PACSIN1 is highly expressed in the brain and at lower leves in the heart, pancreas, and liver. PACSIN1 may play a role in vesicle formation and transport. PACSIN1 has been shown to interact with DNM1, PACSIN3, Huntingtin, and PACSIN2. In addition, PACSIN1 is phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC).

重组蛋白

DNM1 Protein, Human, Recombinant (His)
Cat.No: TMPH-01254
Species: Human
Expression System: E. coli
DNM1L Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-01255
Species: Human
Expression System: E. coli
MOB4 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01406
Species: Human
Expression System: E. coli
PACSIN1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01307
Species: Human
Expression System: Human Cells
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