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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T9846	5-HT3 antagonist 5
	5-HT3 antagonist 5 是喹喔啉 -2- 甲酰胺化合物，是一种5-HT3受体拮抗剂。5-HT3 antagonist 5 对5-HT3激动剂和2-甲基-5-HT 也具有拮抗作用，并在小鼠中表现出抗抑郁作用。
T67956L	Litoxetine HCl litoxetine HCL(86811-09-8 Free base)	5-HT Receptor	GPCR/G Protein; Neuroscience
	Litoxetine HCl 是一种选择性5-羟色胺（5-HT）再摄取抑制剂（SSRI）和混合5-羟色胺拮抗剂，可用于治疗尿失禁。Litoxetine HCl 在没有抗毒蕈碱特性的浓度下（10 nM-1 microM）引起大鼠离体食道肌肉粘膜的浓度依赖性松弛，使卡巴胆碱张力降低达37%,更高浓度的Litoxetine HCl（3微摩-300微摩）与明显的松弛有关，直至取消卡巴胆碱张力。以前在离体豚鼠肠道中证明的利托西汀的抗心律失常活性，在浓度大于1 microM 时在大鼠离体食道肌肉粘膜中发挥了作用。 Litoxetine HCl 的5-HT 释放作用可以解释利托西汀对未处理的大鼠组织中的5-HT 诱导的松弛的效力，这种效力被pCPA 处理所逆转。
T8437	3-(4-prop-2-en-1-ylpiperazin-1-yl)quinox	Others	Others
	3-(4-prop-2-en-1-ylpiperazin-1-yl)quinox 拮抗 2-methyl-5-HT 诱导的豚鼠回肠收缩。
T27269	Ensaculin HCl KA 672,KA672,Ensaculin,Anseculin Hydrochloride,KA-672 HCl
	Ensaculin is a NMDA antagonist and a 5HT1A agonist potentially for the treatment of Alzheimer's disease (AD). Ensaculin showed memory-enhancing effects in paradigms of passive and conditioned avoidance in both normal and artificially amnesic rodents. It e
T35994	Erastin2 Erastin2
	Erastin2 is a ferroptosis inducer and an inhibitor of the system xc- cystine/glutamate transporter.[1] [2] It inhibits glutamate release in CCF-STTG1 cells (IC50 = 0.0035 &#181M).[2] It induces cell death in HAP1 cells when used at a concentration of 5 &#181M, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 or deferoxamine . [1] Erastin2 also induces ferroptotic cell death in HT-1080 cells (EC50 = 0.15 &#181M), an effect that can be blocked by the reducing agent β-merc...
T37246	Palonosetron N-oxide
	Palonosetron N-oxide is a metabolite of the serotonin (5-HT) receptor subtype 5-HT3antagonist palonosetron .1It is also a potential impurity in palonosetron preparations.2Palonosetron N-oxide is a degradation product formed by exposure to oxidative stress. 1.Stoltz, R.A., Cyong, J.-C., Shah, A., et al.Pharmacokinetic and safety evaluation of palonosetron, a 5-hydroxytryptamine-3 receptor antagonist, in U.S. and Japanese healthy subjectsJ. Clin. Pharmacol.44(5)520-531(2004) 2.Vishnu Murthy, M., S...
T36639	Donecopride (fumarate hydrate)
	Donecopride is a partial agonist of the serotonin (5-HT) receptor subtype 5-HT4E(Ki= 8.5 nM) and an inhibitor of acetylcholinesterase (AChE; IC50= 16 nM).1It is selective for AChE over butyrylcholinesterase (BChE; IC50= 3,530 nM) but does bind to 5-HT2Band sigma-2 (σ2) receptors (Ki= 1.6 nM for both) in a panel of 42 neurotransmitter receptors and transporters. Donecopride induces release of soluble amyloid precursor protein-α (sAPP-α) in COS-7 cells transiently expressing 5-HT4with an EC50value...
T38145	Eltoprazine
	Eltoprazine(DU28853) is a serenic or antiaggressive agent which as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor.IC50 value:Target: 5-HT1A/1B agonist; 5-HT2C antagonistin vitro: The binding of [3H]eltoprazine to whole tissue sections was saturable and revealed an apparent dissociation constant (Kd) of 11 nM. Specific [3H]eltoprazine binding was completely displaced by 5-HT; conversely, unlabelled eltoprazine reduced [3H]5-HT binding to the levels of no...
T35775	HT-2 Toxin-13C22 HT-2 Toxin-13C22
	HT-2 toxin-13C22is intended for use as an internal standard for the quantification of HT-2 toxin by GC- or LC-MS. HT-2 toxin is a type A trichothecene mycotoxin and an active, deacetylated metabolite of the trichothecene mycotoxin T-2 toxin .1,2Like T-2 toxin, HT-2 toxin inhibits protein synthesis and cell proliferation in plants.2HT-2 toxin also reduces viability of HepG2, A549, HEp-2, Caco-2, A-204, U937, Jurkat, and RPMI-8226 cancer cells with IC50values ranging from 3.1 to 23 ng/ml and human...
T36521	Alaproclate (hydrochloride)
	Alaproclate is a selective serotonin reuptake inhibitor (SSRI).1,2 It inhibits depletion of serotonin (5-HT) induced by 4-methyl-α-ethyl-m-tyramine in rat cerebral cortex, hippocampus, hypothalamus, and striatum (EC50s = 18, 4, 8, and 12 mg/kg, respectively).1 Alaproclate inhibits NMDA-evoked currents and depolarization-induced voltage-dependent potassium currents in rat hippocampal neurons (IC50s = 1.1 and 6.9 μM, respectively) and does not inhibit GABA-evoked currents when used at concentratio...

化合物

Synonym: litoxetine HCL(86811-09-8 Free base)

Target: 5-HT Receptor

3-(4-prop-2-en-1-ylpiperazin-1-yl)quinox

Synonym: KA 672,KA672,Ensaculin,Anseculin Hydrochloride,KA-672 HCl

Target:

Erastin2

Cat.No: T35994

Synonym: Erastin2

Donecopride (fumarate hydrate)

Synonym: HT-2 Toxin-13C22

Target:

Alaproclate (hydrochloride)

Cat.No: T36521

Synonym:

Target:

Cat. No.	Product Name	Target	Signaling Pathways
T37067	9-hydroxy Stearic Acid	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	9-hydroxy Stearic Acid 是一种羟基脂肪酸，是9-PAHSA 的活性代谢物。9-hydroxy Stearic Acid 是由9-PAHSA 通过肝脏和胰腺的羧基酯脂肪酶形成的。9-hydroxy Stearic Acid (5 μM)抑制HT-29结肠癌细胞裂解物中组蛋白去乙酰化酶1 (HDAC1)的表达。3 .当浓度为100 μM.1时，可抑制HT-29细胞的增殖，并诱导细胞周期阻滞于G0/ g1期。

天然产物

9-hydroxy Stearic Acid

Cat.No: T37067

Synonym:

Target: HDAC

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